Dispase

Dispase is a protease which cleaves fibronectin, collagen IV, and to a lesser extent collagen I. It is found in some bacteria and can be isolated from culture filtrates of Bacillus polymyxa. It can be extracted, purified, and used in research. It can be particularly useful to separate embryonic epithelia and mesenchyme. Dispase II is specific for the cleavage of Leucine-Phenylalanine bonds.

A recent article^[1] also finds that dispase can digest serine-phenylalanine.

References

1. ^ Weimer et. al. Analytical Biochemistry 352 (2006) 110–119