HLA-B57

Disease

HLA-B*5701 is associated with drug-induced inflammatory disease of the skin. Individuals with B57 are more sensitive to the drug abacavir.cite journal |author=Chung WH, Hung SI, Chen YT |title=Human leukocyte antigens and drug hypersensitivity |journal=Curr Opin Allergy Clin Immunol |volume=7 |issue=4 |pages=317–23 |year=2007 |month=August |pmid=17620823 |doi=10.1097/ACI.0b013e3282370c5f |url=] Abacavir is an antiretroviral drug used in treatment of HIV, however in sensitive individuals fever, skin rash, fatigue, gastrointestinal symptoms such as nausea, vomiting, diarrhea or abdominal pain and respiratory symptoms such as pharyngitis, dyspnea, or cough can develop. FDA has advised that people from at-risk ethnic groups, (see table on the left) be screened prior to drug-therapy.http://www.fda.gov/cder/drug/InfoSheets/HCP/abacavirHCP.htm FDA abacavir alert web access July 29, 2008 ] [Note: phenotype frequencies are roughly double allele frequencies -tabled values- when allele frequency is less than 30%]

References