Gabexate

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IUPAC_name = ethyl 4- [6-(diaminomethylideneamino)hexanoyloxy] benzoate


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CAS_number = 39492-01-8
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PubChem = 3447
C = 16 |H = 23 |N = 3 |O = 4
molecular_weight = 311.37 g/mol
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Gabexate mesilate or gabexate is a serine protease inhibitor which is used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulationcite journal |author=Yuksel M, Okajima K, Uchiba M, Okabe H |title=Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappaB and activator protein-1 in human monocytes |journal=J. Pharmacol. Exp. Ther. |volume=305 |issue=1 |pages=298–305 |year=2003 |pmid=12649382 |doi=10.1124/jpet.102.041988 |url=http://jpet.aspetjournals.org/cgi/reprint/305/1/298.pdf] , and as a regional anticoagulant for haemodialysis.cite journal |author=Cavallini G, Tittobello A, Frulloni L, Masci E, Mariana A, Di Francesco V |title=Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. Gabexate in digestive endoscopy--Italian Group |journal=N. Engl. J. Med. |volume=335 |issue=13 |pages=919–23 |year=1996 |pmid=8786777 |doi= |url=http://content.nejm.org/cgi/reprint/335/13/919.pdf]

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