Annonacin

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ImageFile=Annonacin.pngImageSize=200px
IUPACName= (5"S")-5-Methyl-3- [(2"R",8"R",13"R")-2,8,13-trihydroxy-13- [(2"R",5"R")-5- [(1"R")-1- hydroxytridecyl] -2-tetrahydrofuranyl] tridecyl] -5"H"-furan-2-one
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Section1=Chembox Identifiers
CASNo=111035-65-5
PubChem=354398
SMILES=CCCCCCCCCCCCC(C1CCC(O1)C(CCCCC(CCCCCC(CC2=CC(OC2=O)C)O)O)O)O
Section2=Chembox Properties
Formula=C₃₅H₆₄O₇
MolarMass=596.88 g/mol
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Annonacin is a chemical found in fruits such as the guanabana. It is a member of the class of compounds known as acetogenins. Recent reports have shown that daily consumption in rats caused brain lesions consistent with Parkinson's disease.cite journal
last =Lannuzel
first =A
coauthors = et al.
title =The mitochondrial complex i inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism
journal =Neuroscience
volume =121
issue =2
pages =287–296
publisher =International Brain Research Organization
date =6th October 2003
accessdate =2006-12-13
doi =10.1016/S0306-4522(03)00441-X ] [cite journal| author=Champy, Pierre; Hoeglinger, Guenter U.; Feger, Jean; Gleye, Christophe; Hocquemiller, Reynald; Laurens, Alain; Guerineau, Vincent; Laprevote, Olivier; Medja, Fadia; Lombes, Anne; Michel, Patrick P.; Lannuzel, Annie; Hirsch, Etienne C.; Ruberg, Merle |title= Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: Possible relevance for atypical parkinsonism in Guadeloupe |journal=Journal of Neurochemistry |year=2004 |volume=88 |issue=1 |pages= 63–69]

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