PTGES

Prostaglandin E synthase, also known as PTGES, is a human gene.cite web | title = Entrez Gene: PTGES prostaglandin E synthase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9536| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.cite web | title = Entrez Gene: PTGES prostaglandin E synthase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9536| accessdate = ]

ee also

* Prostaglandin E synthase

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bastien L, Sawyer N, Grygorczyk R, "et al." |title=Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 11873–7 |year= 1994 |pmid= 8163486 |doi=
*cite journal | author=Funk CD, Furci L, FitzGerald GA, "et al." |title=Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26767–72 |year= 1994 |pmid= 8253813 |doi=
*cite journal | author=Polyak K, Xia Y, Zweier JL, "et al." |title=A model for p53-induced apoptosis. |journal=Nature |volume=389 |issue= 6648 |pages= 300–5 |year= 1997 |pmid= 9305847 |doi= 10.1038/38525
*cite journal | author=Giacomini E, Giordani L, di Modugno F, "et al." |title=Increased PGE2 production mediates the in vitro inhibitory effect of the human immunodeficiency virus P24 immunosuppressive heptapeptide Ch7. |journal=Scand. J. Immunol. |volume=48 |issue= 3 |pages= 248–53 |year= 1998 |pmid= 9743208 |doi=
*cite journal | author=Jakobsson PJ, Morgenstern R, Mancini J, "et al." |title=Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism. |journal=Protein Sci. |volume=8 |issue= 3 |pages= 689–92 |year= 1999 |pmid= 10091672 |doi=
*cite journal | author=Jakobsson PJ, Thorén S, Morgenstern R, Samuelsson B |title=Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 13 |pages= 7220–5 |year= 1999 |pmid= 10377395 |doi=
*cite journal | author=Forsberg L, Leeb L, Thorén S, "et al." |title=Human glutathione dependent prostaglandin E synthase: gene structure and regulation. |journal=FEBS Lett. |volume=471 |issue= 1 |pages= 78–82 |year= 2000 |pmid= 10760517 |doi=
*cite journal | author=Han R, Smith TJ |title=Cytoplasmic prostaglandin E2 synthase is dominantly expressed in cultured KAT-50 thyrocytes, cells that express constitutive prostaglandin-endoperoxide H synthase-2. Basis for low protaglandin E2 production. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36897–903 |year= 2002 |pmid= 12145315 |doi= 10.1074/jbc.M206949200
*cite journal | author=Giannoulias D, Alfaidy N, Holloway AC, "et al." |title=Expression of prostaglandin I(2) synthase, but not prostaglandin E synthase, changes in myometrium of women at term pregnancy. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 11 |pages= 5274–82 |year= 2002 |pmid= 12414902 |doi=
*cite journal | author=Ouellet M, Falgueyret JP, Ear PH, "et al." |title=Purification and characterization of recombinant microsomal prostaglandin E synthase-1. |journal=Protein Expr. Purif. |volume=26 |issue= 3 |pages= 489–95 |year= 2003 |pmid= 12460774 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Uracz W, Uracz D, Olszanecki R, Gryglewski RJ |title=Interleukin 1beta induces functional prostaglandin E synthase in cultured human umbilical vein endothelial cells. |journal=J. Physiol. Pharmacol. |volume=53 |issue= 4 Pt 1 |pages= 643–54 |year= 2003 |pmid= 12512699 |doi=
*cite journal | author=Meadows JW, Eis AL, Brockman DE, Myatt L |title=Expression and localization of prostaglandin E synthase isoforms in human fetal membranes in term and preterm labor. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 1 |pages= 433–9 |year= 2003 |pmid= 12519887 |doi=
*cite journal | author=Kamei D, Murakami M, Nakatani Y, "et al." |title=Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. |journal=J. Biol. Chem. |volume=278 |issue= 21 |pages= 19396–405 |year= 2003 |pmid= 12626523 |doi= 10.1074/jbc.M213290200
*cite journal | author=Jakobsson PJ, Thorén S, Morgenstern R, Samuelsson B |title=Characterization of microsomal, glutathione dependent prostaglandin E synthase. |journal=Adv. Exp. Med. Biol. |volume=507 |issue= |pages= 287–91 |year= 2003 |pmid= 12664599 |doi=
*cite journal | author=Thorén S, Weinander R, Saha S, "et al." |title=Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination. |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 22199–209 |year= 2003 |pmid= 12672824 |doi= 10.1074/jbc.M303227200
*cite journal | author=Alfaidy N, Sun M, Challis JR, Gibb W |title=Expression of membrane prostaglandin E synthase in human placenta and fetal membranes and effect of labor. |journal=Endocrine |volume=20 |issue= 3 |pages= 219–25 |year= 2003 |pmid= 12721500 |doi=
*cite journal | author=Ekström L, Lyrenäs L, Jakobsson PJ, "et al." |title=Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3. |journal=Biochim. Biophys. Acta |volume=1627 |issue= 2-3 |pages= 79–84 |year= 2003 |pmid= 12818425 |doi=
*cite journal | author=Murakami M, Nakashima K, Kamei D, "et al." |title=Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. |journal=J. Biol. Chem. |volume=278 |issue= 39 |pages= 37937–47 |year= 2003 |pmid= 12835322 |doi= 10.1074/jbc.M305108200
*cite journal | author=Trebino CE, Stock JL, Gibbons CP, "et al." |title=Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 15 |pages= 9044–9 |year= 2003 |pmid= 12835414 |doi= 10.1073/pnas.1332766100

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