Spore photoproduct lyase

Spore photoproduct lyase is an enzyme that repairs a particular kind of lesion that arises upon UV-radiation of bacterial DNA. This repair mechanism is one of the reasons for the resilience of certain bacterial spores. The enzyme is radical-SAM dependent. Through a series of radical reactions the photodimer, 3 5-thyminyl-5,6-dihydrothymine, is disconnected to give back two functional thymine rings. [cite journal | author = Susan C. Wang and Perry A. Frey | title = S-adenosylmethionine as an oxidant: the radical SAM superfamily | journal = Trends in Biochemical Sciences | year = 2007 | volume = 32 | pages = 101 | doi = 10.1016/j.tibs.2007.01.002.Note that the SPL drawings are incorrect in this paper and the erratum] [cite journal | author = Jeffrey M. Buis, Jennifer Cheek, Efthalia Kalliri, and Joan B. Broderick | title = Characterization of an Active Spore Photoproduct Lyase, a DNA Repair Enzyme in the Radical S-Adenosylmethionine Superfamily | journal = Journal of Biological Chemistry | year = 2006 | volume = 281| pages = 25994–26003 | doi = 10.1074/jbc.M603931200.]

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