Vascular endothelial growth factor A
- Vascular endothelial growth factor A
Vascular endothelial growth factor A (VEGF-A) is the most important type of Vascular endothelial growth factors. Before the discovery of similar proteins to what now is the "VEGF sub-family", VEGF-A was called simply VEGF.
As its name implies, VEGF-A activity has been mostly studied on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g. stimulation monocyte/macrophage migration, neurons, cancer cells, kidney epithelial cells ). "In vitro", VEGF-A has been shown to stimulate endothelial cell mitogenesis and cell migration. VEGF-A is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor.
Functions
* Angiogenesis
** ↑ Migration of endothelial cells
** ↑ mitosis of endothelial cells
** ↑ MMOP activity
** ↑ αvβ3 activity
** creation of blood vessel lumen
** creates lumen
** creates fenestrations
*Chemotactic for macrophages and granulocytes
* Vasodilation (indirectly by NO release)
ee also
*Vascular endothelial growth factor
References
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