- EI24
Etoposide induced 2.4 mRNA, also known as EI24, is a human
gene .cite web | title = Entrez Gene: EI24 etoposide induced 2.4 mRNA| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9538| accessdate = ]PBB_Summary
section_title =
summary_text = This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms.cite web | title = Entrez Gene: EI24 etoposide induced 2.4 mRNA| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9538| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Polyak K, Xia Y, Zweier JL, "et al." |title=A model for p53-induced apoptosis. |journal=Nature |volume=389 |issue= 6648 |pages= 300–5 |year= 1997 |pmid= 9305847 |doi= 10.1038/38525
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Gu Z, Flemington C, Chittenden T, Zambetti GP |title=ei24, a p53 response gene involved in growth suppression and apoptosis. |journal=Mol. Cell. Biol. |volume=20 |issue= 1 |pages= 233–41 |year= 2000 |pmid= 10594026 |doi=
*cite journal | author=Gu Z, Gilbert DJ, Valentine VA, "et al." |title=The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9. |journal=Cytogenet. Cell Genet. |volume=89 |issue= 3-4 |pages= 230–3 |year= 2000 |pmid= 10965130 |doi=
*cite journal | author=Burns TF, Bernhard EJ, El-Deiry WS |title=Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo. |journal=Oncogene |volume=20 |issue= 34 |pages= 4601–12 |year= 2001 |pmid= 11498783 |doi= 10.1038/sj.onc.1204484
*cite journal | author=Gentile M, Ahnström M, Schön F, Wingren S |title=Candidate tumour suppressor genes at 11q23-q24 in breast cancer: evidence of alterations in PIG8, a gene involved in p53-induced apoptosis. |journal=Oncogene |volume=20 |issue= 53 |pages= 7753–60 |year= 2002 |pmid= 11753653 |doi= 10.1038/sj.onc.1204993
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026PBB_Controls
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