COX7A2L

Cytochrome c oxidase subunit VIIa polypeptide 2 like, also known as COX7A2L, is a human gene.cite web | title = Entrez Gene: COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9167| accessdate = ]

PBB_Summary
section_title =
summary_text = Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen.cite web | title = Entrez Gene: COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9167| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Segade F, Hurlé B, Claudio E, "et al." |title=Identification of an additional member of the cytochrome c oxidase subunit VIIa family of proteins. |journal=J. Biol. Chem. |volume=271 |issue= 21 |pages= 12343–9 |year= 1996 |pmid= 8647836 |doi=
*cite journal | author=Watanabe T, Inoue S, Hiroi H, "et al." |title=Isolation of estrogen-responsive genes with a CpG island library. |journal=Mol. Cell. Biol. |volume=18 |issue= 1 |pages= 442–9 |year= 1998 |pmid= 9418891 |doi=
*cite journal | author=Schmidt TR, Goodman M, Grossman LI |title=Molecular evolution of the COX7A gene family in primates. |journal=Mol. Biol. Evol. |volume=16 |issue= 5 |pages= 619–26 |year= 1999 |pmid= 10335655 |doi=
*cite journal | author=Lee N, Daly MJ, Delmonte T, "et al." |title=A genomewide linkage-disequilibrium scan localizes the Saguenay-Lac-Saint-Jean cytochrome oxidase deficiency to 2p16. |journal=Am. J. Hum. Genet. |volume=68 |issue= 2 |pages= 397–409 |year= 2001 |pmid= 11156535 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Schmidt TR, Doan JW, Goodman M, Grossman LI |title=Retention of a duplicate gene through changes in subcellular targeting: an electron transport protein homologue localizes to the golgi. |journal=J. Mol. Evol. |volume=57 |issue= 2 |pages= 222–8 |year= 2004 |pmid= 14562965 |doi= 10.1007/s00239-003-2468-8
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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