LHX4

LIM homeobox 4, also known as LHX4, is a human gene.cite web | title = Entrez Gene: LHX4 LIM homeobox 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=89884| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of the pituitary gland. Mutations in this gene are associated with syndromic short stature and pituitary and hindbrain defects. An alternative splice variant has been described but its biological nature has not been determined.cite web | title = Entrez Gene: LHX4 LIM homeobox 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=89884| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Li H, Witte DP, Branford WW, "et al." |title=Gsh-4 encodes a LIM-type homeodomain, is expressed in the developing central nervous system and is required for early postnatal survival. |journal=EMBO J. |volume=13 |issue= 12 |pages= 2876–85 |year= 1994 |pmid= 7913017 |doi=
*cite journal | author=Howard PW, Maurer RA |title=Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors. |journal=J. Biol. Chem. |volume=275 |issue= 18 |pages= 13336–42 |year= 2000 |pmid= 10788441 |doi=
*cite journal | author=Machinis K, Pantel J, Netchine I, "et al." |title=Syndromic short stature in patients with a germline mutation in the LIM homeobox LHX4. |journal=Am. J. Hum. Genet. |volume=69 |issue= 5 |pages= 961–8 |year= 2001 |pmid= 11567216 |doi=
*cite journal | author=Liu Y, Fan M, Yu S, "et al." |title=cDNA cloning, chromosomal localization and expression pattern analysis of human LIM-homeobox gene LHX4. |journal=Brain Res. |volume=928 |issue= 1-2 |pages= 147–55 |year= 2002 |pmid= 11844481 |doi=
*cite journal | author=Kawamata N, Sakajiri S, Sugimoto KJ, "et al." |title=A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute lymphoblastic leukemia involves the LIM homeodomain protein gene, Lhx4. |journal=Oncogene |volume=21 |issue= 32 |pages= 4983–91 |year= 2002 |pmid= 12118377 |doi= 10.1038/sj.onc.1205628
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Dattani MT |title=Borjeson-Forssman-Lehmann syndrome: a novel pituitary phenotype due to mutation in a novel gene. |journal=J. Pediatr. Endocrinol. Metab. |volume=16 |issue= 9 |pages= 1207–9 |year= 2004 |pmid= 14714741 |doi=
*cite journal | author=Sobrier ML, Attié-Bitach T, Netchine I, "et al." |title=Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development. |journal=Gene Expr. Patterns |volume=5 |issue= 2 |pages= 279–84 |year= 2006 |pmid= 15567726 |doi= 10.1016/j.modgep.2004.07.003
*cite journal | author=Machinis K, Amselem S |title=Functional relationship between LHX4 and POU1F1 in light of the LHX4 mutation identified in patients with pituitary defects. |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 9 |pages= 5456–62 |year= 2005 |pmid= 15998782 |doi= 10.1210/jc.2004-2332

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