- HSD17B6
Hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse), also known as HSD17B6, is a human
gene .cite web | title = Entrez Gene: HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8630| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. Transcript variants utilizing alternative polyadenylation signals exist.cite web | title = Entrez Gene: HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8630| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Baker ME |title=Evolution of 17beta-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action. |journal=Mol. Cell. Endocrinol. |volume=171 |issue= 1-2 |pages= 211–5 |year= 2001 |pmid= 11165032 |doi=
*cite journal | author=Biswas MG, Russell DW |title=Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate. |journal=J. Biol. Chem. |volume=272 |issue= 25 |pages= 15959–66 |year= 1997 |pmid= 9188497 |doi=
*cite journal | author=Huang XF, Luu-The V |title=Molecular characterization of a first human 3(alpha-->beta)-hydroxysteroid epimerase. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29452–7 |year= 2000 |pmid= 10896656 |doi= 10.1074/jbc.M000562200
*cite journal | author=Kedishvili NY, Belyaeva OV, Gough WH |title=Cloning of the human RoDH-related short chain dehydrogenase gene and analysis of its structure. |journal=Chem. Biol. Interact. |volume=130-132 |issue= 1-3 |pages= 457–67 |year= 2001 |pmid= 11306067 |doi=
*cite journal | author=Chetyrkin SV, Hu J, Gough WH, "et al." |title=Further characterization of human microsomal 3alpha-hydroxysteroid dehydrogenase. |journal=Arch. Biochem. Biophys. |volume=386 |issue= 1 |pages= 1–10 |year= 2001 |pmid= 11360992 |doi= 10.1006/abbi.2000.2203
*cite journal | author=Huang XF, Luu-The V |title=Gene structure, chromosomal localization and analysis of 3-ketosteroid reductase activity of the human 3(alpha-->beta)-hydroxysteroid epimerase. |journal=Biochim. Biophys. Acta |volume=1520 |issue= 2 |pages= 124–30 |year= 2001 |pmid= 11513953 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Jones MR, Italiano L, Wilson SG, "et al." |title=Polymorphism in HSD17B6 is associated with key features of polycystic ovary syndrome. |journal=Fertil. Steril. |volume=86 |issue= 5 |pages= 1438–46 |year= 2006 |pmid= 17070195 |doi= 10.1016/j.fertnstert.2006.04.027
*cite journal | author=Belyaeva OV, Chetyrkin SV, Clark AL, "et al." |title=Role of microsomal retinol/sterol dehydrogenase-like short-chain dehydrogenases/reductases in the oxidation and epimerization of 3alpha-hydroxysteroids in human tissues. |journal=Endocrinology |volume=148 |issue= 5 |pages= 2148–56 |year= 2007 |pmid= 17289849 |doi= 10.1210/en.2006-1491PBB_Controls
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