CA11

CA11

Carbonic anhydrase XI, also known as CA11, is a human gene.cite web | title = Entrez Gene: CA11 carbonic anhydrase XI| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=770| accessdate = ]

PBB_Summary
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summary_text = Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system.cite web | title = Entrez Gene: CA11 carbonic anhydrase XI| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=770| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lovejoy DA, Hewett-Emmett D, Porter CA, "et al." |title=Evolutionarily conserved, "acatalytic" carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3. |journal=Genomics |volume=54 |issue= 3 |pages= 48493 |year= 1999 |pmid= 9878252 |doi= 10.1006/geno.1998.5585
*cite journal | author=Bellingham J, Gregory-Evans K, Gregory-Evans CY |title=Sequence and tissue expression of a novel human carbonic anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3. |journal=Biochem. Biophys. Res. Commun. |volume=253 |issue= 2 |pages= 3647 |year= 1999 |pmid= 9878543 |doi= 10.1006/bbrc.1998.9449
*cite journal | author=Fujikawa-Adachi K, Nishimori I, Taguchi T, "et al." |title=cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI. |journal=Biochim. Biophys. Acta |volume=1431 |issue= 2 |pages= 51824 |year= 1999 |pmid= 10350627 |doi=
*cite journal | author=Okamoto N, Fujikawa-Adachi K, Nishimori I, "et al." |title=cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA expressions of CA-RP X and XI in human brain. |journal=Biochim. Biophys. Acta |volume=1518 |issue= 3 |pages= 3116 |year= 2001 |pmid= 11311946 |doi=
*cite journal | author=Taniuchi K, Nishimori I, Takeuchi T, "et al." |title=Developmental expression of carbonic anhydrase-related proteins VIII, X, and XI in the human brain. |journal=Neuroscience |volume=112 |issue= 1 |pages= 939 |year= 2002 |pmid= 12044474 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 226570 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 21217 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Liu T, Qian WJ, Gritsenko MA, "et al." |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 207080 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065

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