MRPL40

Mitochondrial ribosomal protein L40, also known as MRPL40, is a human gene.cite web | title = Entrez Gene: MRPL40 mitochondrial ribosomal protein L40| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64976| accessdate = ]

PBB_Summary
section_title =
summary_text = Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome.cite web | title = Entrez Gene: MRPL40 mitochondrial ribosomal protein L40| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64976| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Funke B, Puech A, Saint-Jore B, "et al." |title=Isolation and characterization of a human gene containing a nuclear localization signal from the critical region for velo-cardio-facial syndrome on 22q11. |journal=Genomics |volume=53 |issue= 2 |pages= 146–54 |year= 1998 |pmid= 9790763 |doi= 10.1006/geno.1998.5488
*cite journal | author=Goldschmidt-Reisin S, Kitakawa M, Herfurth E, "et al." |title=Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 34828–36 |year= 1999 |pmid= 9857009 |doi=
*cite journal | author=Hildebrandt T, Preiherr J, Klostermann S, "et al." |title=Identification of URIM, a novel gene up-regulated in metastasis. |journal=Anticancer Res. |volume=19 |issue= 1A |pages= 525–30 |year= 1999 |pmid= 10226592 |doi=
*cite journal | author=Kenmochi N, Suzuki T, Uechi T, "et al." |title=The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. |journal=Genomics |volume=77 |issue= 1-2 |pages= 65–70 |year= 2001 |pmid= 11543634 |doi= 10.1006/geno.2001.6622
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhang Z, Gerstein M |title=Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. |journal=Genomics |volume=81 |issue= 5 |pages= 468–80 |year= 2003 |pmid= 12706105 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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