- TBCA
Tubulin folding cofactor A, also known as TBCA, is a human
gene .cite web | title = Entrez Gene: TBCA tubulin folding cofactor A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6902| accessdate = ]PBB_Summary
section_title =
summary_text = The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A.cite web | title = Entrez Gene: TBCA tubulin folding cofactor A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6902| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Lewis SA, Tian G, Vainberg IE, Cowan NJ |title=Chaperonin-mediated folding of actin and tubulin. |journal=J. Cell Biol. |volume=132 |issue= 1-2 |pages= 1–4 |year= 1996 |pmid= 8567715 |doi=
*cite journal | author=Tian G, Huang Y, Rommelaere H, "et al." |title=Pathway leading to correctly folded beta-tubulin. |journal=Cell |volume=86 |issue= 2 |pages= 287–96 |year= 1996 |pmid= 8706133 |doi=
*cite journal | author=Mao M, Fu G, Wu JS, "et al." |title=Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 8175–80 |year= 1998 |pmid= 9653160 |doi=
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=
*cite journal | author=Guasch A, Aloria K, Pérez R, "et al." |title=Three-dimensional structure of human tubulin chaperone cofactor A. |journal=J. Mol. Biol. |volume=318 |issue= 4 |pages= 1139–49 |year= 2002 |pmid= 12054808 |doi= 10.1016/S0022-2836(02)00185-7
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Nolasco S, Bellido J, Gonçalves J, "et al." |title=Tubulin cofactor A gene silencing in mammalian cells induces changes in microtubule cytoskeleton, cell cycle arrest and cell death. |journal=FEBS Lett. |volume=579 |issue= 17 |pages= 3515–24 |year= 2005 |pmid= 15963512 |doi= 10.1016/j.febslet.2005.05.022
*cite journal | author=Bruneel A, Labas V, Mailloux A, "et al." |title=Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. |journal=Proteomics |volume=5 |issue= 15 |pages= 3876–84 |year= 2006 |pmid= 16130169 |doi= 10.1002/pmic.200401239PBB_Controls
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