SSX5

Synovial sarcoma, X breakpoint 5, also known as SSX5, is a human gene.cite web | title = Entrez Gene: SSX5 synovial sarcoma, X breakpoint 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6758| accessdate = ]

PBB_Summary
section_title =
summary_text = The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This gene appears not to be involved in this type of chromosome translocation. Two transcript variants encoding distinct isoforms have been identified for this gene.cite web | title = Entrez Gene: SSX5 synovial sarcoma, X breakpoint 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6758| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=dos Santos NR, de Bruijn DR, van Kessel AG |title=Molecular mechanisms underlying human synovial sarcoma development. |journal=Genes Chromosomes Cancer |volume=30 |issue= 1 |pages= 1–14 |year= 2001 |pmid= 11107170 |doi=
*cite journal | author=Gure AO, Türeci O, Sahin U, "et al." |title=SSX: a multigene family with several members transcribed in normal testis and human cancer. |journal=Int. J. Cancer |volume=72 |issue= 6 |pages= 965–71 |year= 1997 |pmid= 9378559 |doi=
*cite journal | author=Chen CH, Chen GJ, Lee HS, "et al." |title=Expressions of cancer-testis antigens in human hepatocellular carcinomas. |journal=Cancer Lett. |volume=164 |issue= 2 |pages= 189–95 |year= 2001 |pmid= 11179834 |doi=
*cite journal | author=de Bruijn DR, dos Santos NR, Kater-Baats E, "et al." |title=The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. |journal=Genes Chromosomes Cancer |volume=34 |issue= 3 |pages= 285–98 |year= 2002 |pmid= 12007189 |doi= 10.1002/gcc.10073
*cite journal | author=Güre AO, Wei IJ, Old LJ, Chen YT |title=The SSX gene family: characterization of 9 complete genes. |journal=Int. J. Cancer |volume=101 |issue= 5 |pages= 448–53 |year= 2002 |pmid= 12216073 |doi= 10.1002/ijc.10634
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ross MT, Grafham DV, Coffey AJ, "et al." |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440
*cite journal | author=Wu LQ, Lu Y, Wang XF, "et al." |title=Expression of cancer-testis antigen (CTA) in tumor tissues and peripheral blood of Chinese patients with hepatocellular carcinoma. |journal=Life Sci. |volume=79 |issue= 8 |pages= 744–8 |year= 2006 |pmid= 16546222 |doi= 10.1016/j.lfs.2006.02.024

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