- PPP3CC
Protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform, also known as PPP3CC, is a human
gene .cite web | title = Entrez Gene: PPP3CC protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5533| accessdate = ]PBB_Summary
section_title =
summary_text = Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha (CALNA1; MIM 114105), calcineurin A-beta (CALNA2; MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity). [supplied by OMIM] cite web | title = Entrez Gene: PPP3CC protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5533| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Muramatsu T, Kincaid RL |title=Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A). |journal=Biochem. Biophys. Res. Commun. |volume=188 |issue= 1 |pages= 265–71 |year= 1992 |pmid= 1339277 |doi=
*cite journal | author=Esau C, Boes M, Youn HD, "et al." |title=Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells. |journal=J. Exp. Med. |volume=194 |issue= 10 |pages= 1449–59 |year= 2001 |pmid= 11714752 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bennasser Y, Badou A, Tkaczuk J, Bahraoui E |title=Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. |journal=Virology |volume=303 |issue= 1 |pages= 174–80 |year= 2003 |pmid= 12482669 |doi=
*cite journal | author=Gerber DJ, Hall D, Miyakawa T, "et al." |title=Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 15 |pages= 8993–8 |year= 2003 |pmid= 12851458 |doi= 10.1073/pnas.1432927100
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, "et al." |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776
*cite journal | author=Eastwood SL, Burnet PW, Harrison PJ |title=Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia. |journal=Biol. Psychiatry |volume=57 |issue= 7 |pages= 702–10 |year= 2005 |pmid= 15820226 |doi= 10.1016/j.biopsych.2004.12.029
*cite journal | author=Kinoshita Y, Suzuki T, Ikeda M, "et al." |title=No association with the calcineurin A gamma subunit gene (PPP3CC) haplotype to Japanese schizophrenia. |journal=Journal of neural transmission (Vienna, Austria : 1996) |volume=112 |issue= 9 |pages= 1255–62 |year= 2006 |pmid= 15843870 |doi= 10.1007/s00702-004-0261-5
*cite journal | author=Liu YL, Fann CS, Liu CM, "et al." |title=More evidence supports the association of PPP3CC with schizophrenia. |journal=Mol. Psychiatry |volume=12 |issue= 10 |pages= 966–74 |year= 2008 |pmid= 17339875 |doi= 10.1038/sj.mp.4001977
*cite journal | author=Horiuchi Y, Ishiguro H, Koga M, "et al." |title=Support for association of the PPP3CC gene with schizophrenia. |journal=Mol. Psychiatry |volume=12 |issue= 10 |pages= 891–3 |year= 2008 |pmid= 17895921 |doi= 10.1038/sj.mp.4002019PBB_Controls
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