A2BP1

Ataxin 2-binding protein 1, also known as A2BP1, is a human gene.cite web | title = Entrez Gene: A2BP1 ataxin 2-binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54715| accessdate = ]

PBB_Summary
section_title =
summary_text = Ataxin-2 binding protein 1 has an RNP motif that is highly conserved among RNA-binding proteins. This protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the gene product of the SCA2 gene which causes familial neurodegenerative diseases. Ataxin-2 binding protein 1 and ataxin-2 are both localized in the trans-Golgi network. Four alternatively spliced transcript variants have been found for this gene. Additional transcript variants have been found but their full length nature has not been determined.cite web | title = Entrez Gene: A2BP1 ataxin 2-binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54715| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Shibata H, Huynh DP, Pulst SM |title=A novel protein with RNA-binding motifs interacts with ataxin-2. |journal=Hum. Mol. Genet. |volume=9 |issue= 9 |pages= 1303–13 |year= 2000 |pmid= 10814712 |doi=
*cite journal | author=Kiehl TR, Shibata H, Vo T, "et al." |title=Identification and expression of a mouse ortholog of A2BP1. |journal=Mamm. Genome |volume=12 |issue= 8 |pages= 595–601 |year= 2002 |pmid= 11471052 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Underwood JG, Boutz PL, Dougherty JD, "et al." |title=Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals. |journal=Mol. Cell. Biol. |volume=25 |issue= 22 |pages= 10005–16 |year= 2005 |pmid= 16260614 |doi= 10.1128/MCB.25.22.10005-10016.2005
*cite journal | author=Auweter SD, Fasan R, Reymond L, "et al." |title=Molecular basis of RNA recognition by the human alternative splicing factor Fox-1. |journal=EMBO J. |volume=25 |issue= 1 |pages= 163–73 |year= 2006 |pmid= 16362037 |doi= 10.1038/sj.emboj.7600918
*cite journal | author=Ponthier JL, Schluepen C, Chen W, "et al." |title=Fox-2 splicing factor binds to a conserved intron motif to promote inclusion of protein 4.1R alternative exon 16. |journal=J. Biol. Chem. |volume=281 |issue= 18 |pages= 12468–74 |year= 2006 |pmid= 16537540 |doi= 10.1074/jbc.M511556200
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Zhou HL, Baraniak AP, Lou H |title=Role for Fox-1/Fox-2 in mediating the neuronal pathway of calcitonin/calcitonin gene-related peptide alternative RNA processing. |journal=Mol. Cell. Biol. |volume=27 |issue= 3 |pages= 830–41 |year= 2007 |pmid= 17101796 |doi= 10.1128/MCB.01015-06

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