CLEC4A

C-type lectin domain family 4, member A, also known as CLEC4A, is a human gene.cite web | title = Entrez Gene: CLEC4A C-type lectin domain family 4, member A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50856| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.cite web | title = Entrez Gene: CLEC4A C-type lectin domain family 4, member A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50856| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Drickamer K |title=C-type lectin-like domains. |journal=Curr. Opin. Struct. Biol. |volume=9 |issue= 5 |pages= 585–90 |year= 1999 |pmid= 10508765 |doi=
*cite journal | author=Bates EE, Fournier N, Garcia E, "et al." |title=APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. |journal=J. Immunol. |volume=163 |issue= 4 |pages= 1973–83 |year= 1999 |pmid= 10438934 |doi=
*cite journal | author=Huang X, Yuan Z, Chen G, "et al." |title=Cloning and characterization of a novel ITIM containing lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants. |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 1 |pages= 131–40 |year= 2001 |pmid= 11178971 |doi= 10.1006/bbrc.2001.4322
*cite journal | author=Richard M, Veilleux P, Rouleau M, "et al." |title=The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation. |journal=J. Leukoc. Biol. |volume=71 |issue= 5 |pages= 871–80 |year= 2002 |pmid= 11994513 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ebner S, Sharon N, Ben-Tal N |title=Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. |journal=Proteins |volume=53 |issue= 1 |pages= 44–55 |year= 2003 |pmid= 12945048 |doi= 10.1002/prot.10440
*cite journal | author=Richard M, Thibault N, Veilleux P, "et al." |title=The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents. |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 3 |pages= 767–73 |year= 2003 |pmid= 14550269 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Richard M, Thibault N, Veilleux P, "et al." |title=Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: a new mechanism of action for SHP-2. |journal=Mol. Immunol. |volume=43 |issue= 10 |pages= 1716–21 |year= 2006 |pmid= 16360206 |doi= 10.1016/j.molimm.2005.10.006
*cite journal | author=Lorentzen JC, Flornes L, Eklöw C, "et al." |title=Association of arthritis with a gene complex encoding C-type lectin-like receptors. |journal=Arthritis Rheum. |volume=56 |issue= 8 |pages= 2620–32 |year= 2007 |pmid= 17665455 |doi= 10.1002/art.22813

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