INSM1

Insulinoma-associated 1, also known as INSM1, is a human gene.cite web | title = Entrez Gene: INSM1 insulinoma-associated 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3642| accessdate = ]

PBB_Summary
section_title =
summary_text = Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.cite web | title = Entrez Gene: INSM1 insulinoma-associated 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3642| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Goto Y, De Silva MG, Toscani A, "et al." |title=A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs. |journal=J. Biol. Chem. |volume=267 |issue= 21 |pages= 15252–7 |year= 1992 |pmid= 1634555 |doi=
*cite journal | author=Lan MS, Li Q, Lu J, "et al." |title=Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1. |journal=J. Biol. Chem. |volume=269 |issue= 19 |pages= 14170–4 |year= 1994 |pmid= 8188699 |doi=
*cite journal | author=Li Q, Notkins AL, Lan MS |title=Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1. |journal=Biochem. Biophys. Res. Commun. |volume=236 |issue= 3 |pages= 776–81 |year= 1997 |pmid= 9245732 |doi= 10.1006/bbrc.1997.7054
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Breslin MB, Zhu M, Notkins AL, Lan MS |title=Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence. |journal=Nucleic Acids Res. |volume=30 |issue= 4 |pages= 1038–45 |year= 2002 |pmid= 11842116 |doi=
*cite journal | author=Zhu M, Breslin MB, Lan MS |title=Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells. |journal=Pancreas |volume=24 |issue= 2 |pages= 139–45 |year= 2002 |pmid= 11854618 |doi=
*cite journal | author=Xie J, Cai T, Zhang H, "et al." |title=The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein. |journal=Genomics |volume=80 |issue= 1 |pages= 54–61 |year= 2003 |pmid= 12079283 |doi=
*cite journal | author=Breslin MB, Zhu M, Lan MS |title=NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 38991–7 |year= 2003 |pmid= 12890672 |doi= 10.1074/jbc.M306795200
*cite journal | author=Liu WD, Wang HW, Muguira M, "et al." |title=INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases. |journal=Biochem. J. |volume=397 |issue= 1 |pages= 169–77 |year= 2006 |pmid= 16569215 |doi= 10.1042/BJ20051669

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