FRAT2

Frequently rearranged in advanced T-cell lymphomas 2, also known as FRAT2, is a human gene.cite web | title = Entrez Gene: FRAT2 frequently rearranged in advanced T-cell lymphomas 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23401| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.cite web | title = Entrez Gene: FRAT2 frequently rearranged in advanced T-cell lymphomas 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23401| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Yost C, Farr GH, Pierce SB, "et al." |title=GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. |journal=Cell |volume=93 |issue= 6 |pages= 1031–41 |year= 1998 |pmid= 9635432 |doi=
*cite journal | author=Saitoh T, Moriwaki J, Koike J, "et al." |title=Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway. |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 3 |pages= 815–20 |year= 2001 |pmid= 11237732 |doi= 10.1006/bbrc.2001.4421
*cite journal | author=Bax B, Carter PS, Lewis C, "et al." |title=The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation. |journal=Structure |volume=9 |issue= 12 |pages= 1143–52 |year= 2002 |pmid= 11738041 |doi=
*cite journal | author=Freemantle SJ, Portland HB, Ewings K, "et al." |title=Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2. |journal=Gene |volume=291 |issue= 1-2 |pages= 17–27 |year= 2002 |pmid= 12095675 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Stoothoff WH, Cho JH, McDonald RP, Johnson GV |title=FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation. |journal=J. Biol. Chem. |volume=280 |issue= 1 |pages= 270–6 |year= 2005 |pmid= 15522877 |doi= 10.1074/jbc.M410061200

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