WFDC5

WFDC5

WAP four-disulfide core domain 5, also known as WFDC5, is a human gene.cite web | title = Entrez Gene: WFDC5 WAP four-disulfide core domain 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=149708| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.cite web | title = Entrez Gene: WFDC5 WAP four-disulfide core domain 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=149708| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Horikoshi N, Cong J, Kley N, Shenk T |title=Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene. |journal=Biochem. Biophys. Res. Commun. |volume=261 |issue= 3 |pages= 864–9 |year= 1999 |pmid= 10441517 |doi= 10.1006/bbrc.1999.1123
*cite journal | author=Ranganathan S, Simpson KJ, Shaw DC, Nicholas KR |title=The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling. |journal=J. Mol. Graph. Model. |volume=17 |issue= 2 |pages= 106–13, 134–6 |year= 2000 |pmid= 10680116 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Clauss A, Lilja H, Lundwall A |title=A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. |journal=Biochem. J. |volume=368 |issue= Pt 1 |pages= 233–42 |year= 2002 |pmid= 12206714 |doi= 10.1042/BJ20020869
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Nukumi N, Seki M, Iwamori T, "et al." |title=Analysis of the promoter of mutated human whey acidic protein (WAP) gene. |journal=J. Reprod. Dev. |volume=52 |issue= 2 |pages= 315–20 |year= 2006 |pmid= 16462094 |doi=
*cite journal | author=Mukhopadhyay SS, Rosen JM |title=The C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells. |journal=Biochem. Biophys. Res. Commun. |volume=358 |issue= 3 |pages= 770–6 |year= 2007 |pmid= 17511965 |doi= 10.1016/j.bbrc.2007.04.185

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