- TRIM3
Tripartite motif-containing 3, also known as TRIM3, is a human
gene .cite web | title = Entrez Gene: TRIM3 tripartite motif-containing 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10612| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified.cite web | title = Entrez Gene: TRIM3 tripartite motif-containing 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10612| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=El-Husseini AE, Vincent SR |title=Cloning and characterization of a novel RING finger protein that interacts with class V myosins. |journal=J. Biol. Chem. |volume=274 |issue= 28 |pages= 19771–7 |year= 1999 |pmid= 10391919 |doi=
*cite journal | author=El-Husseini AE, Kwasnicka D, Yamada T, "et al." |title=BERP, a novel ring finger protein, binds to alpha-actinin-4. |journal=Biochem. Biophys. Res. Commun. |volume=267 |issue= 3 |pages= 906–11 |year= 2000 |pmid= 10673389 |doi= 10.1006/bbrc.1999.2045
*cite journal | author=El-Husseini AE, Fretier P, Vincent SR |title=Cloning and characterization of a gene (RNF22) encoding a novel brain expressed ring finger protein (BERP) that maps to human chromosome 11p15.5. |journal=Genomics |volume=71 |issue= 3 |pages= 363–7 |year= 2001 |pmid= 11170753 |doi= 10.1006/geno.2000.6452
*cite journal | author=Reymond A, Meroni G, Fantozzi A, "et al." |title=The tripartite motif family identifies cell compartments. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2140–51 |year= 2001 |pmid= 11331580 |doi= 10.1093/emboj/20.9.2140
*cite journal | author=Lee SJ, Choi JY, Sung YM, "et al." |title=E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme. |journal=FEBS Lett. |volume=503 |issue= 1 |pages= 61–4 |year= 2001 |pmid= 11513855 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Yan Q, Sun W, Kujala P, "et al." |title=CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling. |journal=Mol. Biol. Cell |volume=16 |issue= 5 |pages= 2470–82 |year= 2005 |pmid= 15772161 |doi= 10.1091/mbc.E04-11-1014
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026PBB_Controls
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