CPNE1

Copine I, also known as CPNE1, is a human gene.cite web | title = Entrez Gene: CPNE1 copine I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8904| accessdate = ]

PBB_Summary
section_title =
summary_text = Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Sequence analysis identified multiple alternatively spliced variants in the 5' UTR. All variants encode the same protein.cite web | title = Entrez Gene: CPNE1 copine I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8904| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Creutz CE, Tomsig JL, Snyder SL, "et al." |title=The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans. |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1393–402 |year= 1998 |pmid= 9430674 |doi=
*cite journal | author=Savino M, d'Apolito M, Centra M, "et al." |title=Characterization of copine VII, a new member of the copine family, and its exclusion as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3. |journal=Genomics |volume=61 |issue= 2 |pages= 219–26 |year= 1999 |pmid= 10534407 |doi= 10.1006/geno.1999.5958
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tomsig JL, Snyder SL, Creutz CE |title=Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10048–54 |year= 2003 |pmid= 12522145 |doi= 10.1074/jbc.M212632200
*cite journal | author=Cowland JB, Carter D, Bjerregaard MD, "et al." |title=Tissue expression of copines and isolation of copines I and III from the cytosol of human neutrophils. |journal=J. Leukoc. Biol. |volume=74 |issue= 3 |pages= 379–88 |year= 2003 |pmid= 12949241 |doi=
*cite journal | author=Tomsig JL, Sohma H, Creutz CE |title=Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by copine. |journal=Biochem. J. |volume=378 |issue= Pt 3 |pages= 1089–94 |year= 2004 |pmid= 14674885 |doi= 10.1042/BJ20031654
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Ma J, Dempsey AA, Stamatiou D, "et al." |title=Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. |journal=Atherosclerosis |volume=191 |issue= 1 |pages= 63–72 |year= 2007 |pmid= 16806233 |doi= 10.1016/j.atherosclerosis.2006.05.032

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