SNX27

Sorting nexin family member 27, also known as SNX27, is a human gene.cite web | title = Entrez Gene: SNX27 sorting nexin family member 27| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81609| accessdate = ]

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of the serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.cite web | title = Entrez Gene: SNX27 sorting nexin family member 27| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81609| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Worby CA, Dixon JE |title=Sorting out the cellular functions of sorting nexins. |journal=Nat. Rev. Mol. Cell Biol. |volume=3 |issue= 12 |pages= 919–31 |year= 2003 |pmid= 12461558 |doi= 10.1038/nrm974
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Seki N, Ohira M, Nagase T, "et al." |title=Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. |journal=DNA Res. |volume=4 |issue= 5 |pages= 345–9 |year= 1998 |pmid= 9455484 |doi=
*cite journal | author=Teasdale RD, Loci D, Houghton F, "et al." |title=A large family of endosome-localized proteins related to sorting nexin 1. |journal=Biochem. J. |volume=358 |issue= Pt 1 |pages= 7–16 |year= 2001 |pmid= 11485546 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Williams R, Schlüter T, Roberts MS, "et al." |title=Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin. |journal=Mol. Biol. Cell |volume=15 |issue= 7 |pages= 3095–105 |year= 2005 |pmid= 15121882 |doi= 10.1091/mbc.E04-02-0143
*cite journal | author=Joubert L, Hanson B, Barthet G, "et al." |title=New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting. |journal=J. Cell. Sci. |volume=117 |issue= Pt 22 |pages= 5367–79 |year= 2005 |pmid= 15466885 |doi= 10.1242/jcs.01379
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Rincón E, Santos T, Avila-Flores A, "et al." |title=Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling. |journal=Mol. Cell Proteomics |volume=6 |issue= 6 |pages= 1073–87 |year= 2007 |pmid= 17351151 |doi= 10.1074/mcp.M700047-MCP200
*cite journal | author=MacNeil AJ, Mansour M, Pohajdak B |title=Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes. |journal=Biochem. Biophys. Res. Commun. |volume=359 |issue= 4 |pages= 848–53 |year= 2007 |pmid= 17577583 |doi= 10.1016/j.bbrc.2007.05.162

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