MRPS11

Mitochondrial ribosomal protein S11, also known as MRPS11, is a human gene.cite web | title = Entrez Gene: MRPS11 mitochondrial ribosomal protein S11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64963| accessdate = ]

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summary_text = Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Sequence analysis identified two transcript variants that encode different protein isoforms.cite web | title = Entrez Gene: MRPS11 mitochondrial ribosomal protein S11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64963| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Cavdar Koc E, Burkhart W, Blackburn K, "et al." |title=The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19363–74 |year= 2001 |pmid= 11279123 |doi= 10.1074/jbc.M100727200
*cite journal | author=Suzuki T, Terasaki M, Takemoto-Hori C, "et al." |title=Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 33181–95 |year= 2001 |pmid= 11402041 |doi= 10.1074/jbc.M103236200
*cite journal | author=Kenmochi N, Suzuki T, Uechi T, "et al." |title=The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. |journal=Genomics |volume=77 |issue= 1-2 |pages= 65–70 |year= 2001 |pmid= 11543634 |doi= 10.1006/geno.2001.6622
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhang Z, Gerstein M |title=Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. |journal=Genomics |volume=81 |issue= 5 |pages= 468–80 |year= 2003 |pmid= 12706105 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Ishiguchi H, Izumi H, Torigoe T, "et al." |title=ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA. |journal=Int. J. Cancer |volume=111 |issue= 6 |pages= 900–9 |year= 2004 |pmid= 15300802 |doi= 10.1002/ijc.20358
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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