HHIP

Hedgehog interacting protein, also known as HHIP, is a human gene.cite web | title = Entrez Gene: HHIP hedgehog interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64399| accessdate = ]

This gene encodes a protein similar to the mouse hedgehog-interacting protein, a regulatory component of the Hedgehog signaling pathway. Members of the hedgehog family are evolutionarily conserved proteins which are involved in many fundamental processes in embryonic development, including anteroposterior patterns of limbs and regulation of left-right asymmetry.cite web | title = Entrez Gene: HHIP hedgehog interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64399| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ingham PW, McMahon AP |title=Hedgehog signaling in animal development: paradigms and principles. |journal=Genes Dev. |volume=15 |issue= 23 |pages= 3059–87 |year= 2001 |pmid= 11731473 |doi= 10.1101/gad.938601
*cite journal | author=Chuang PT, McMahon AP |title=Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. |journal=Nature |volume=397 |issue= 6720 |pages= 617–21 |year= 1999 |pmid= 10050855 |doi= 10.1038/17611
*cite journal | author=Bak M, Hansen C, Friis Henriksen K, Tommerup N |title=The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21-->q31.3. |journal=Cytogenet. Cell Genet. |volume=92 |issue= 3-4 |pages= 300–3 |year= 2001 |pmid= 11435703 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Olsen CL, Hsu PP, Glienke J, "et al." |title=Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors. |journal=BMC Cancer |volume=4 |issue= |pages= 43 |year= 2004 |pmid= 15294024 |doi= 10.1186/1471-2407-4-43
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kayed H, Kleeff J, Esposito I, "et al." |title=Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas. |journal=Mol. Carcinog. |volume=42 |issue= 4 |pages= 183–92 |year= 2005 |pmid= 15754313 |doi= 10.1002/mc.20088
*cite journal | author=Martin ST, Sato N, Dhara S, "et al." |title=Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms. |journal=Cancer Biol. Ther. |volume=4 |issue= 7 |pages= 728–33 |year= 2006 |pmid= 15970691 |doi=

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