C8orf4

Chromosome 8 open reading frame 4, also known as C8orf4, is a human gene.cite web | title = Entrez Gene: C8orf4 chromosome 8 open reading frame 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56892| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes.cite web | title = Entrez Gene: C8orf4 chromosome 8 open reading frame 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56892| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Chua EL, Young L, Wu WM, "et al." |title=Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer. |journal=Genomics |volume=69 |issue= 3 |pages= 342–7 |year= 2001 |pmid= 11056052 |doi= 10.1006/geno.2000.6348
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sunde M, McGrath KC, Young L, "et al." |title=TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer. |journal=Cancer Res. |volume=64 |issue= 8 |pages= 2766–73 |year= 2004 |pmid= 15087392 |doi=
*cite journal | author=Friedman JB, Brunschwig EB, Platzer P, "et al." |title=C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer. |journal=Int. J. Cancer |volume=111 |issue= 1 |pages= 72–5 |year= 2004 |pmid= 15185345 |doi= 10.1002/ijc.20235
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Jung Y, Bang S, Choi K, "et al." |title=TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby. |journal=Cancer Res. |volume=66 |issue= 2 |pages= 723–8 |year= 2006 |pmid= 16424001 |doi= 10.1158/0008-5472.CAN-05-3124
*cite journal | author=Kim B, Koo H, Yang S, "et al." |title=TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer. |journal=Clin. Cancer Res. |volume=12 |issue= 11 Pt 1 |pages= 3541–8 |year= 2007 |pmid= 16740781 |doi= 10.1158/1078-0432.CCR-05-2440
*cite journal | author=Yang ZQ, Streicher KL, Ray ME, "et al." |title=Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer. |journal=Cancer Res. |volume=66 |issue= 24 |pages= 11632–43 |year= 2007 |pmid= 17178857 |doi= 10.1158/0008-5472.CAN-06-2946
*cite journal | author=Yang ZQ, Moffa AB, Haddad R, "et al." |title=Transforming properties of TC-1 in human breast cancer: interaction with FGFR2 and beta-catenin signaling pathways. |journal=Int. J. Cancer |volume=121 |issue= 6 |pages= 1265–73 |year= 2007 |pmid= 17520678 |doi= 10.1002/ijc.22831
*cite journal | author=Park J, Jung Y, Kim J, "et al." |title=TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response. |journal=Biochem. Biophys. Res. Commun. |volume=360 |issue= 2 |pages= 447–52 |year= 2007 |pmid= 17603013 |doi= 10.1016/j.bbrc.2007.06.077

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