WDR12

WD repeat domain 12, also known as WDR12, is a human gene.cite web | title = Entrez Gene: WDR12 WD repeat domain 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55759| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The function of this protein is not known.cite web | title = Entrez Gene: WDR12 WD repeat domain 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55759| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Andersen JS, Lyon CE, Fox AH, "et al." |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=
*cite journal | author=Nal B, Mohr E, Silva MI, "et al." |title=Wdr12, a mouse gene encoding a novel WD-Repeat Protein with a notchless-like amino-terminal domain. |journal=Genomics |volume=79 |issue= 1 |pages= 77–86 |year= 2002 |pmid= 11827460 |doi= 10.1006/geno.2001.6682
*cite journal | author=Scherl A, Couté Y, Déon C, "et al." |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100–9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Andersen JS, Lam YW, Leung AK, "et al." |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207
*cite journal | author=Hölzel M, Rohrmoser M, Schlee M, "et al." |title=Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. |journal=J. Cell Biol. |volume=170 |issue= 3 |pages= 367–78 |year= 2005 |pmid= 16043514 |doi= 10.1083/jcb.200501141
*cite journal | author=Higa LA, Wu M, Ye T, "et al." |title=CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. |journal=Nat. Cell Biol. |volume=8 |issue= 11 |pages= 1277–83 |year= 2006 |pmid= 17041588 |doi= 10.1038/ncb1490
*cite journal | author=Rohrmoser M, Hölzel M, Grimm T, "et al." |title=Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. |journal=Mol. Cell. Biol. |volume=27 |issue= 10 |pages= 3682–94 |year= 2007 |pmid= 17353269 |doi= 10.1128/MCB.00172-07

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