Asporin

Asporin, also known as ASPN, is a human gene.cite web | title = Entrez Gene: ASPN asporin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54829| accessdate = ]

PBB_Summary
section_title =
summary_text = ASPN belongs to a family of leucine-rich repeat (LRR) proteins associated with the cartilage matrix. The name asporin reflects the unique aspartate-rich N terminus and the overall similarity to decorin (MIM 125255) (Lorenzo et al., 2001). [supplied by OMIM] cite web | title = Entrez Gene: ASPN asporin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54829| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lorenzo P, Aspberg A, Onnerfjord P, "et al." |title=Identification and characterization of asporin. a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan. |journal=J. Biol. Chem. |volume=276 |issue= 15 |pages= 12201–11 |year= 2001 |pmid= 11152692 |doi= 10.1074/jbc.M010932200
*cite journal | author=Henry SP, Takanosu M, Boyd TC, "et al." |title=Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family. |journal=J. Biol. Chem. |volume=276 |issue= 15 |pages= 12212–21 |year= 2001 |pmid= 11152695 |doi= 10.1074/jbc.M011290200
*cite journal | author=Yamada S, Murakami S, Matoba R, "et al." |title=Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene. |journal=Gene |volume=275 |issue= 2 |pages= 279–86 |year= 2001 |pmid= 11587855 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Kizawa H, Kou I, Iida A, "et al." |title=An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. |journal=Nat. Genet. |volume=37 |issue= 2 |pages= 138–44 |year= 2005 |pmid= 15640800 |doi= 10.1038/ng1496
*cite journal | author=Rodriguez-Lopez J, Pombo-Suarez M, Liz M, "et al." |title=Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians. |journal=Arthritis Res. Ther. |volume=8 |issue= 3 |pages= R55 |year= 2006 |pmid= 16542493 |doi= 10.1186/ar1920
*cite journal | author=Yamada S, Ozawa Y, Tomoeda M, "et al." |title=Regulation of PLAP-1 expression in periodontal ligament cells. |journal=J. Dent. Res. |volume=85 |issue= 5 |pages= 447–51 |year= 2006 |pmid= 16632759 |doi=
*cite journal | author=Jiang Q, Shi D, Yi L, "et al." |title=Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese. |journal=J. Hum. Genet. |volume=51 |issue= 12 |pages= 1068–72 |year= 2007 |pmid= 17024313 |doi= 10.1007/s10038-006-0065-6
*cite journal | author=Nakamura T, Shi D, Tzetis M, "et al." |title=Meta-analysis of association between the ASPN D-repeat and osteoarthritis. |journal=Hum. Mol. Genet. |volume=16 |issue= 14 |pages= 1676–81 |year= 2007 |pmid= 17517696 |doi= 10.1093/hmg/ddm115
*cite journal | author=Shi D, Nakamura T, Dai J, "et al." |title=Association of the aspartic acid-repeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese population. |journal=J. Hum. Genet. |volume=52 |issue= 8 |pages= 664–7 |year= 2007 |pmid= 17603749 |doi= 10.1007/s10038-007-0166-x
*cite journal | author=Kou I, Nakajima M, Ikegawa S |title=Expression and regulation of the osteoarthritis-associated protein asporin. |journal=J. Biol. Chem. |volume=282 |issue= 44 |pages= 32193–9 |year= 2007 |pmid= 17804408 |doi= 10.1074/jbc.M706262200
*cite journal | author=Nakajima M, Kizawa H, Saitoh M, "et al." |title=Mechanisms for asporin function and regulation in articular cartilage. |journal=J. Biol. Chem. |volume=282 |issue= 44 |pages= 32185–92 |year= 2007 |pmid= 17827158 |doi= 10.1074/jbc.M700522200

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes