TREM2

Triggering receptor expressed on myeloid cells 2, also known as TREM2, is a human gene.cite web | title = Entrez Gene: TREM2 triggering receptor expressed on myeloid cells 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54209| accessdate = ]

PBB_Summary
section_title =
summary_text = Monocyte/macrophage- and neutrophil-mediated inflammatory responses can be stimulated through a variety of receptors, including G protein-linked 7-transmembrane receptors (e.g., FPR1; MIM 136537), Fc receptors (see MIM 146790), CD14 (MIM 158120) and Toll-like receptors (e.g., TLR4; MIM 603030), and cytokine receptors (e.g., IFNGR1; MIM 107470). Engagement of these receptors can also prime myeloid cells to respond to other stimuli. Myeloid cells express receptors belonging to the Ig superfamily, such as TREM2, or to the C-type lectin superfamily. Depending on their transmembrane and cytoplasmic sequence structure, these receptors have either activating (e.g., KIR2DS1; MIM 604952) or inhibitory functions (e.g., KIR2DL1; MIM 604936). [supplied by OMIM] cite web | title = Entrez Gene: TREM2 triggering receptor expressed on myeloid cells 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54209| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bouchon A, Dietrich J, Colonna M |title=Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. |journal=J. Immunol. |volume=164 |issue= 10 |pages= 4991–5 |year= 2000 |pmid= 10799849 |doi=
*cite journal | author=Paloneva J, Manninen T, Christman G, "et al." |title=Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. |journal=Am. J. Hum. Genet. |volume=71 |issue= 3 |pages= 656–62 |year= 2002 |pmid= 12080485 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Allcock RJ, Barrow AD, Forbes S, "et al." |title=The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. |journal=Eur. J. Immunol. |volume=33 |issue= 2 |pages= 567–77 |year= 2003 |pmid= 12645956 |doi= 10.1002/immu.200310033
*cite journal | author=Soragna D, Papi L, Ratti MT, "et al." |title=An Italian family affected by Nasu-Hakola disease with a novel genetic mutation in the TREM2 gene. |journal=J. Neurol. Neurosurg. Psychiatr. |volume=74 |issue= 6 |pages= 825–6 |year= 2003 |pmid= 12754369 |doi=
*cite journal | author=Cella M, Buonsanti C, Strader C, "et al." |title=Impaired differentiation of osteoclasts in TREM-2-deficient individuals. |journal=J. Exp. Med. |volume=198 |issue= 4 |pages= 645–51 |year= 2003 |pmid= 12913093 |doi= 10.1084/jem.20022220
*cite journal | author=Paloneva J, Mandelin J, Kiialainen A, "et al." |title=DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features. |journal=J. Exp. Med. |volume=198 |issue= 4 |pages= 669–75 |year= 2003 |pmid= 12925681 |doi= 10.1084/jem.20030027
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Montalbetti L, Ratti MT, Greco B, "et al." |title=Neuropsychological tests and functional nuclear neuroimaging provide evidence of subclinical impairment in Nasu-Hakola disease heterozygotes. |journal=Funct. Neurol. |volume=20 |issue= 2 |pages= 71–5 |year= 2005 |pmid= 15966270 |doi=
*cite journal | author=Bianchin MM, Lima JE, Natel J, Sakamoto AC |title=The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2. |journal=Neurology |volume=66 |issue= 4 |pages= 615–6; author reply 615–6 |year= 2006 |pmid= 16505336 |doi= 10.1212/01.wnl.0000216105.11788.0f

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes