PPM1G

Protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform, also known as PPM1G, is a human gene.cite web | title = Entrez Gene: PPM1G protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5496| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.cite web | title = Entrez Gene: PPM1G protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5496| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Guthridge MA, Bellosta P, Tavoloni N, Basilico C |title=FIN13, a novel growth factor-inducible serine-threonine phosphatase which can inhibit cell cycle progression. |journal=Mol. Cell. Biol. |volume=17 |issue= 9 |pages= 5485–98 |year= 1997 |pmid= 9271424 |doi=
*cite journal | author=Travis SM, Welsh MJ |title=PP2C gamma: a human protein phosphatase with a unique acidic domain. |journal=FEBS Lett. |volume=412 |issue= 3 |pages= 415–9 |year= 1997 |pmid= 9276438 |doi=
*cite journal | author=Murray MV, Kobayashi R, Krainer AR |title=The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor. |journal=Genes Dev. |volume=13 |issue= 1 |pages= 87–97 |year= 1999 |pmid= 9887102 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Flajolet M, Rakhilin S, Wang H, "et al." |title=Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 26 |pages= 16006–11 |year= 2004 |pmid= 14663150 |doi= 10.1073/pnas.2136600100
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Maynes JT, Luu HA, Cherney MM, "et al." |title=Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins. |journal=J. Mol. Biol. |volume=356 |issue= 1 |pages= 111–20 |year= 2006 |pmid= 16343532 |doi= 10.1016/j.jmb.2005.11.019
*cite journal | author=Suh EJ, Kim TY, Kim SH |title=PP2Cgamma-mediated S-phase accumulation induced by the proteasome-dependent degradation of p21(WAF1/CIP1). |journal=FEBS Lett. |volume=580 |issue= 26 |pages= 6100–4 |year= 2007 |pmid= 17054950 |doi= 10.1016/j.febslet.2006.10.005
*cite journal | author=Kimura H, Takizawa N, Allemand E, "et al." |title=A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B. |journal=J. Cell Biol. |volume=175 |issue= 3 |pages= 389–400 |year= 2006 |pmid= 17074886 |doi= 10.1083/jcb.200608001
*cite journal | author=Luo W, Peterson A, Garcia BA, "et al." |title=Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. |journal=EMBO J. |volume=26 |issue= 6 |pages= 1511–21 |year= 2007 |pmid= 17318175 |doi= 10.1038/sj.emboj.7601607
*cite journal | author=Allemand E, Hastings ML, Murray MV, "et al." |title=Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1. |journal=Nat. Struct. Mol. Biol. |volume=14 |issue= 7 |pages= 630–8 |year= 2007 |pmid= 17572683 |doi= 10.1038/nsmb1257
*cite journal | author=Petri S, Grimmler M, Over S, "et al." |title=Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complex. |journal=J. Cell Biol. |volume=179 |issue= 3 |pages= 451–65 |year= 2007 |pmid= 17984321 |doi= 10.1083/jcb.200704163

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