ERGIC2

ERGIC and golgi 2, also known as ERGIC2, is a human gene located on human chromosome 12p11. It encodes a protein of 377 amino acid residues. The biological function of ERGIC2 protein is unknown, although it was initially identified as a candidate tumor suppressor of prostate cancer. It is now believed to be a chaperon molecule involved in protein trafficking between endoplasmic reticulum (ER) and Golgi. The protein contains two hydrophobic transmembrane domains that help anchoring the molecule on the ER membrane, such that its large luminal domain orients inside the ER lumen and both the N- and C-termini are facing the cytosol. ERGIC2 forms a complex with two other proteins, hErv46 and ERGIC32, resulting in a shuttle for protein trafficking between ER and Golgi.cite web | title = Entrez Gene: ERGIC2 ERGIC and golgi 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51290| accessdate = ]

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*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Kwok SC, Liu X, Daskal I |title=Molecular cloning, expression, localization, and gene organization of PTX1, a human nuclear protein that is downregulated in prostate cancer. |journal=DNA Cell Biol. |volume=20 |issue= 6 |pages= 349–57 |year= 2001 |pmid= 11445006 |doi= 10.1089/10445490152122460
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Liu X, Daskal I, Kwok SC |title=Effects of PTX1 expression on growth and tumorigenicity of the prostate cancer cell line PC-3. |journal=DNA Cell Biol. |volume=22 |issue= 7 |pages= 469–74 |year= 2003 |pmid= 12932305 |doi= 10.1089/104454903322247343
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Breuza L, Halbeisen R, Jenö P, "et al." |title=Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47242–53 |year= 2004 |pmid= 15308636 |doi= 10.1074/jbc.M406644200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kwok SC, Liu X, Mangel P, Daskal I |title=PTX1(ERGIC2)-VP22 fusion protein upregulates interferon-beta in prostate cancer cell line PC-3. |journal=DNA Cell Biol. |volume=25 |issue= 9 |pages= 523–9 |year= 2006 |pmid= 16989575 |doi= 10.1089/dna.2006.25.523

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