LIM2

Lens intrinsic membrane protein 2, 19kDa, also known as LIM2, is a human gene.cite web | title = Entrez Gene: LIM2 lens intrinsic membrane protein 2, 19kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3982| accessdate = ]

PBB_Summary
section_title =
summary_text = The mammalian lens fiber cell membrane contains 5 major proteins ranging from 70 kD to 19 kD in size. The specific function of these proteins is unknown. Some of them have been shown to be involved in the formation of cataracts, e.g., crystalline-gamma-1 (CRYG1; MIM 123660). The second most abundant intrinsic membrane protein of the lens fiber cell is MP19, so named for major lens protein having a molecular weight of 19.5 kD. This protein appears to contain 4 transmembrane domains, is a substrate for cAMP-dependent protein kinase and protein kinase C, and binds with calmodulin. Taken together, these suggest that MP19 functions in some way as a junctional component, possibly involved with lens cell communication. It has been shown to be involved with cataractogenesis. [supplied by OMIM] cite web | title = Entrez Gene: LIM2 lens intrinsic membrane protein 2, 19kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3982| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Church RL, Wang J |title=Assignment of the lens intrinsic membrane protein MP19 structural gene to human chromosome 19. |journal=Curr. Eye Res. |volume=11 |issue= 5 |pages= 421–4 |year= 1992 |pmid= 1606837 |doi=
*cite journal | author=Louis CF, Hur KC, Galvan AC, "et al." |title=Identification of an 18,000-dalton protein in mammalian lens fiber cell membranes. |journal=J. Biol. Chem. |volume=264 |issue= 33 |pages= 19967–73 |year= 1989 |pmid= 2584203 |doi=
*cite journal | author=Church RL, Wang JH |title=The human lens fiber-cell intrinsic membrane protein MP19 gene: isolation and sequence analysis. |journal=Curr. Eye Res. |volume=12 |issue= 12 |pages= 1057–65 |year= 1994 |pmid= 8137630 |doi=
*cite journal | author=Lieuallen K, Christensen M, Brandriff B, "et al." |title=Assignment of the human lens fiber cell MP19 gene (LIM2) to chromosome 19q13.4, and adjacent to ETFB. |journal=Somat. Cell Mol. Genet. |volume=20 |issue= 1 |pages= 67–9 |year= 1994 |pmid= 8197479 |doi=
*cite journal | author=Kerscher S, Church RL, Boyd Y, Lyon MF |title=Mapping of four mouse genes encoding eye lens-specific structural, gap junction, and integral membrane proteins: Cryba1 (crystallin beta A3/A1), Crybb2 (crystallin beta B2), Gja8 (MP70), and Lim2 (MP19). |journal=Genomics |volume=29 |issue= 2 |pages= 445–50 |year= 1996 |pmid= 8666393 |doi= 10.1006/geno.1995.9983
*cite journal | author=Gonen T, Grey AC, Jacobs MD, "et al." |title=MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3. |journal=BMC Cell Biol. |volume=2 |issue= |pages= 17 |year= 2002 |pmid= 11532191 |doi=
*cite journal | author=Pras E, Levy-Nissenbaum E, Bakhan T, "et al." |title=A missense mutation in the LIM2 gene is associated with autosomal recessive presenile cataract in an inbred Iraqi Jewish family. |journal=Am. J. Hum. Genet. |volume=70 |issue= 5 |pages= 1363–7 |year= 2002 |pmid= 11917274 |doi=
*cite journal | author=Wistow G, Bernstein SL, Ray S, "et al." |title=Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium. |journal=Mol. Vis. |volume=8 |issue= |pages= 185–95 |year= 2002 |pmid= 12107412 |doi=
*cite journal | author=Wistow G, Bernstein SL, Wyatt MK, "et al." |title=Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants. |journal=Mol. Vis. |volume=8 |issue= |pages= 171–84 |year= 2002 |pmid= 12107413 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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