MRPL22

Mitochondrial ribosomal protein L22, also known as MRPL22, is a human gene.cite web | title = Entrez Gene: MRPL22 mitochondrial ribosomal protein L22| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29093| accessdate = ]

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summary_text = Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: MRPL22 mitochondrial ribosomal protein L22| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29093| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Goldschmidt-Reisin S, Kitakawa M, Herfurth E, "et al." |title=Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 34828–36 |year= 1999 |pmid= 9857009 |doi=
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=
*cite journal | author=Kenmochi N, Suzuki T, Uechi T, "et al." |title=The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. |journal=Genomics |volume=77 |issue= 1-2 |pages= 65–70 |year= 2001 |pmid= 11543634 |doi= 10.1006/geno.2001.6622
*cite journal | author=Koc EC, Burkhart W, Blackburn K, "et al." |title=The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 43958–69 |year= 2001 |pmid= 11551941 |doi= 10.1074/jbc.M106510200
*cite journal | author=O'Brien TW |title=Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease. |journal=Gene |volume=286 |issue= 1 |pages= 73–9 |year= 2002 |pmid= 11943462 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhang Z, Gerstein M |title=Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. |journal=Genomics |volume=81 |issue= 5 |pages= 468–80 |year= 2003 |pmid= 12706105 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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