GZMM

Granzyme M (lymphocyte met-ase 1), also known as GZMM, is a human gene.cite web | title = Entrez Gene: GZMM granzyme M (lymphocyte met-ase 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3004| accessdate = ]

PBB_Summary
section_title =
summary_text = Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M.cite web | title = Entrez Gene: GZMM granzyme M (lymphocyte met-ase 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3004| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Smyth MJ, O'Connor MD, Trapani JA |title=Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies. |journal=J. Leukoc. Biol. |volume=60 |issue= 5 |pages= 555–62 |year= 1996 |pmid= 8929545 |doi=
*cite journal | author=Pilat D, Fink T, Obermaier-Skrobanek B, "et al." |title=The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3. |journal=Genomics |volume=24 |issue= 3 |pages= 445–50 |year= 1995 |pmid= 7713495 |doi= 10.1006/geno.1994.1651
*cite journal | author=Baker E, Sutherland GR, Smyth MJ |title=The gene encoding a human natural killer cell granule serine protease, Met-ase 1, maps to chromosome 19p13.3. |journal=Immunogenetics |volume=39 |issue= 4 |pages= 294–5 |year= 1994 |pmid= 8119738 |doi=
*cite journal | author=Smyth MJ, Sayers TJ, Wiltrout T, "et al." |title=Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells. |journal=J. Immunol. |volume=151 |issue= 11 |pages= 6195–205 |year= 1994 |pmid= 8245461 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Krenacs L, Smyth MJ, Bagdi E, "et al." |title=The serine protease granzyme M is preferentially expressed in NK-cell, gamma delta T-cell, and intestinal T-cell lymphomas: evidence of origin from lymphocytes involved in innate immunity. |journal=Blood |volume=101 |issue= 9 |pages= 3590–3 |year= 2003 |pmid= 12506019 |doi= 10.1182/blood-2002-09-2908
*cite journal | author=Kelly JM, Waterhouse NJ, Cretney E, "et al." |title=Granzyme M mediates a novel form of perforin-dependent cell death. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22236–42 |year= 2004 |pmid= 15028722 |doi= 10.1074/jbc.M401670200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Mahrus S, Kisiel W, Craik CS |title=Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B. |journal=J. Biol. Chem. |volume=279 |issue= 52 |pages= 54275–82 |year= 2005 |pmid= 15494398 |doi= 10.1074/jbc.M411482200
*cite journal | author=Lu H, Hou Q, Zhao T, "et al." |title=Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation. |journal=J. Immunol. |volume=177 |issue= 2 |pages= 1171–8 |year= 2006 |pmid= 16818775 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes