PPP2R3B

Protein phosphatase 2 (formerly 2A), regulatory subunit B", beta, also known as PPP2R3B, is a human gene.cite web | title = Entrez Gene: PPP2R3B protein phosphatase 2 (formerly 2A), regulatory subunit B", beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28227| accessdate = ]

PBB_Summary
section_title =
summary_text = Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B"/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B" family. The B" family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B". Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: PPP2R3B protein phosphatase 2 (formerly 2A), regulatory subunit B", beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28227| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Ruediger R, Fields K, Walter G |title=Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens. |journal=J. Virol. |volume=73 |issue= 1 |pages= 839–42 |year= 1999 |pmid= 9847399 |doi=
*cite journal | author=Scanlan MJ, Gordan JD, Williamson B, "et al." |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456–64 |year= 1999 |pmid= 10508479 |doi=
*cite journal | author=Yan Z, Fedorov SA, Mumby MC, Williams RS |title=PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 1021–9 |year= 2000 |pmid= 10629059 |doi=
*cite journal | author=Schiebel K, Meder J, Rump A, "et al." |title=Elevated DNA sequence diversity in the genomic region of the phosphatase PPP2R3L gene in the human pseudoautosomal region. |journal=Cytogenet. Cell Genet. |volume=91 |issue= 1-4 |pages= 224–30 |year= 2001 |pmid= 11173861 |doi=
*cite journal | author=Yokoyama N, Miller WT |title=Protein phosphatase 2A interacts with the Src kinase substrate p130(CAS). |journal=Oncogene |volume=20 |issue= 42 |pages= 6057–65 |year= 2001 |pmid= 11593413 |doi= 10.1038/sj.onc.1204735
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Stevens I, Janssens V, Martens E, "et al." |title=Identification and characterization of B"-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues. |journal=Eur. J. Biochem. |volume=270 |issue= 2 |pages= 376–87 |year= 2003 |pmid= 12605688 |doi=
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Gao Y, Kitagawa K, Hiramatsu Y, "et al." |title=Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis. |journal=Cancer Res. |volume=66 |issue= 24 |pages= 11623–31 |year= 2007 |pmid= 17178856 |doi= 10.1158/0008-5472.CAN-06-2629

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