LDOC1

Leucine zipper, down-regulated in cancer 1, also known as LDOC1, is a human gene.cite web | title = Entrez Gene: LDOC1 leucine zipper, down-regulated in cancer 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23641| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.cite web | title = Entrez Gene: LDOC1 leucine zipper, down-regulated in cancer 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23641| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagasaki K, Manabe T, Hanzawa H, "et al." |title=Identification of a novel gene, LDOC1, down-regulated in cancer cell lines. |journal=Cancer Lett. |volume=140 |issue= 1-2 |pages= 227–34 |year= 1999 |pmid= 10403563 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Nagasaki K, Schem C, von Kaisenberg C, "et al." |title=Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis. |journal=Int. J. Cancer |volume=105 |issue= 4 |pages= 454–8 |year= 2003 |pmid= 12712434 |doi= 10.1002/ijc.11122
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Chih DY, Park DJ, Gross M, "et al." |title=Protein partners of C/EBPepsilon. |journal=Exp. Hematol. |volume=32 |issue= 12 |pages= 1173–81 |year= 2005 |pmid= 15588942 |doi= 10.1016/j.exphem.2004.08.014
*cite journal | author=Inoue M, Takahashi K, Niide O, "et al." |title=LDOC1, a novel MZF-1-interacting protein, induces apoptosis. |journal=FEBS Lett. |volume=579 |issue= 3 |pages= 604–8 |year= 2005 |pmid= 15670815 |doi= 10.1016/j.febslet.2004.12.030
*cite journal | author=Brandt J, Schrauth S, Veith AM, "et al." |title=Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. |journal=Gene |volume=345 |issue= 1 |pages= 101–11 |year= 2005 |pmid= 15716091 |doi= 10.1016/j.gene.2004.11.022
*cite journal | author=Ross MT, Grafham DV, Coffey AJ, "et al." |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440
*cite journal | author=Brandt J, Veith AM, Volff JN |title=A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. |journal=Cytogenet. Genome Res. |volume=110 |issue= 1-4 |pages= 307–17 |year= 2005 |pmid= 16093683 |doi= 10.1159/000084963
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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