- FRG1
FSHD region gene 1, also known as FRG1, is a human
gene .cite web | title = Entrez Gene: FRG1 FSHD region gene 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2483| accessdate = ]PBB_Summary
section_title =
summary_text = This gene maps to a location 100 kb centromeric of the repeat units on chromosome 4q35 which are deleted infacioscapulohumeral muscular dystrophy (FSHD). It is evolutionarily conserved and has related sequences on multiple human chromosomes but DNA sequence analysis did not reveal any homology to known genes. In vivo studies demonstrate the encoded protein is localized to the nucleolus.cite web | title = Entrez Gene: FRG1 FSHD region gene 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2483| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Fisher J, Upadhyaya M |title=Molecular genetics of facioscapulohumeral muscular dystrophy (FSHD). |journal=Neuromuscul. Disord. |volume=7 |issue= 1 |pages= 55–62 |year= 1997 |pmid= 9132141 |doi=
*cite journal | author=van Deutekom JC, Lemmers RJ, Grewal PK, "et al." |title=Identification of the first gene (FRG1) from the FSHD region on human chromosome 4q35. |journal=Hum. Mol. Genet. |volume=5 |issue= 5 |pages= 581–90 |year= 1997 |pmid= 8733123 |doi=
*cite journal | author=van Geel M, Heather LJ, Lyle R, "et al." |title=The FSHD region on human chromosome 4q35 contains potential coding regions among pseudogenes and a high density of repeat elements. |journal=Genomics |volume=61 |issue= 1 |pages= 55–65 |year= 1999 |pmid= 10512680 |doi= 10.1006/geno.1999.5942
*cite journal | author=Jurica MS, Licklider LJ, Gygi SR, "et al." |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=van Koningsbruggen S, Dirks RW, Mommaas AM, "et al." |title=FRG1P is localised in the nucleolus, Cajal bodies, and speckles. |journal=J. Med. Genet. |volume=41 |issue= 4 |pages= e46 |year= 2004 |pmid= 15060122 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Andersen JS, Lam YW, Leung AK, "et al." |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207
*cite journal | author=Gabellini D, D'Antona G, Moggio M, "et al." |title=Facioscapulohumeral muscular dystrophy in mice overexpressing FRG1. |journal=Nature |volume=439 |issue= 7079 |pages= 973–7 |year= 2006 |pmid= 16341202 |doi= 10.1038/nature04422PBB_Controls
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