LECT1

LECT1

Leukocyte cell derived chemotaxin 1, also known as LECT1, is a human gene.cite web | title = Entrez Gene: LECT1 leukocyte cell derived chemotaxin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11061| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: LECT1 leukocyte cell derived chemotaxin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11061| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hiraki Y, Shukunami C |title=Chondromodulin-I as a novel cartilage-specific growth-modulating factor. |journal=Pediatr. Nephrol. |volume=14 |issue= 7 |pages= 602–5 |year= 2000 |pmid= 10912526 |doi=
*cite journal | author=Shukunami C, Hiraki Y |title=Expression of cartilage-specific functional matrix chondromodulin-I mRNA in rabbit growth plate chondrocytes and its responsiveness to growth stimuli in vitro. |journal=Biochem. Biophys. Res. Commun. |volume=249 |issue= 3 |pages= 885–90 |year= 1998 |pmid= 9731231 |doi= 10.1006/bbrc.1998.9233
*cite journal | author=Hiraki Y, Mitsui K, Endo N, "et al." |title=Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells. |journal=Eur. J. Biochem. |volume=260 |issue= 3 |pages= 869–78 |year= 1999 |pmid= 10103018 |doi=
*cite journal | author=Hayami T, Shukunami C, Mitsui K, "et al." |title=Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo. |journal=FEBS Lett. |volume=458 |issue= 3 |pages= 436–40 |year= 2000 |pmid= 10570955 |doi=
*cite journal | author=Yanagihara I, Yamagata M, Sakai N, "et al." |title=Genomic organization of the human chondromodulin-1 gene containing a promoter region that confers the expression of reporter gene in chondrogenic ATDC5 cells. |journal=J. Bone Miner. Res. |volume=15 |issue= 3 |pages= 421–9 |year= 2000 |pmid= 10750556 |doi=
*cite journal | author=Azizan A, Holaday N, Neame PJ |title=Post-translational processing of bovine chondromodulin-I. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23632–8 |year= 2001 |pmid= 11323410 |doi= 10.1074/jbc.M009967200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Aoyama T, Okamoto T, Nagayama S, "et al." |title=Expression of the chondromodulin-I gene in chondrosarcomas. |journal=Cancer Lett. |volume=204 |issue= 1 |pages= 61–8 |year= 2004 |pmid= 14744535 |doi=
*cite journal | author=Aoyama T, Okamoto T, Nagayama S, "et al." |title=Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28789–97 |year= 2004 |pmid= 15107420 |doi= 10.1074/jbc.M401273200
*cite journal | author=Yoshioka M, Yuasa S, Matsumura K, "et al." |title=Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis. |journal=Nat. Med. |volume=12 |issue= 10 |pages= 1151–9 |year= 2006 |pmid= 16980969 |doi= 10.1038/nm1476

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Society — A society is a population of humans characterized by patterns of relationships between individuals that share a distinctive culture and institutions. More broadly, a society is an economic, social and industrial infrastructure in which a varied… …   Wikipedia

  • Homeobox protein NANOG — See NANOG (computing) for the network operators group. Nanog homeobox Identifiers Symbols NANOG; External IDs …   Wikipedia

  • NANOG — NANOG  это транскрипционный фактор, участвующий в самообновлении недифференцированных эмбриональных стволовых клеток. Содержание 1 Эмбриональные стволовые клетки 2 История …   Википедия

  • collect — col|lect1 W2S1 [kəˈlekt] v ▬▬▬▬▬▬▬ 1¦(bring together)¦ 2¦(keep objects)¦ 3¦(rent/debts/taxes)¦ 4¦(money to help people)¦ 5¦(increase in amount)¦ 6¦(win something)¦ 7 collect yourself/collect your thoughts 8¦(take somebody/something from a place)¦ …   Dictionary of contemporary English

  • elect — e|lect1 W3S2 [ıˈlekt] v [T usually passive] [Date: 1400 1500; : Latin; Origin: electus, past participle of eligere to choose ] 1.) to choose someone for an official position by voting ▪ the country s first democratically elected government ▪ a… …   Dictionary of contemporary English

  • select — se|lect1 W2S2 [sıˈlekt] v [T] to choose something or someone by thinking carefully about which is the best, most suitable etc = ↑choose, pick ↑pick ▪ a group of students selected at random select sb for sth ▪ He had hopes of being selected for… …   Dictionary of contemporary English

  • collect — col|lect1 [ kə lekt ] verb *** 1. ) transitive to get things and keep them together for a particular reason: A lot of families collect newspapers for recycling. a ) to get and keep objects because they are interesting or valuable: I didn t know… …   Usage of the words and phrases in modern English

  • elect — e|lect1 [ ı lekt ] verb transitive *** to choose someone by voting so that they represent you or hold an official position: Every nation should have a right to elect their own government. elect someone to do something: We were elected to tackle… …   Usage of the words and phrases in modern English

  • select — se|lect1 [ sı lekt ] verb transitive *** 1. ) to choose someone or something from a group: You can select one of four colors. select someone to do something: We re going to select two students to represent the school. select someone/something for …   Usage of the words and phrases in modern English

  • col|lect´a|ble — col|lect1 «kuh LEHKT», verb, adverb, adjective. –v.t. 1. to bring together; gather together: »We collected sticks of wood to make a fire. SYNONYM(S): See syn. under gather. (Cf. ↑gather) 2. to gather together for a set: »Most boys collect stamps… …   Useful english dictionary

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”