SPAG11B

Sperm associated antigen 11, also known as SPAG11, is a human gene.cite web | title = Entrez Gene: SPAG11 sperm associated antigen 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10407| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined.cite web | title = Entrez Gene: SPAG11 sperm associated antigen 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10407| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kirchhoff C, Osterhoff C, Habben I, "et al." |title=Cloning and analysis of mRNAs expressed specifically in the human epididymis. |journal=Int. J. Androl. |volume=13 |issue= 2 |pages= 155–67 |year= 1990 |pmid= 1693137 |doi=
*cite journal | author=Osterhoff C, Kirchhoff C, Krull N, Ivell R |title=Molecular cloning and characterization of a novel human sperm antigen (HE2) specifically expressed in the proximal epididymis. |journal=Biol. Reprod. |volume=50 |issue= 3 |pages= 516–25 |year= 1994 |pmid= 8167223 |doi=
*cite journal | author=Krull N, Ivell R, Osterhoff C, Kirchhoff C |title=Region-specific variation of gene expression in the human epididymis as revealed by in situ hybridization with tissue-specific cDNAs. |journal=Mol. Reprod. Dev. |volume=34 |issue= 1 |pages= 16–24 |year= 1993 |pmid= 8418812 |doi= 10.1002/mrd.1080340104
*cite journal | author=Hamil KG, Sivashanmugam P, Richardson RT, "et al." |title=HE2beta and HE2gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human. |journal=Endocrinology |volume=141 |issue= 3 |pages= 1245–53 |year= 2000 |pmid= 10698202 |doi=
*cite journal | author=Fröhlich O, Po C, Murphy T, Young LG |title=Multiple promoter and splicing mRNA variants of the epididymis-specific gene EP2. |journal=J. Androl. |volume=21 |issue= 3 |pages= 421–30 |year= 2000 |pmid= 10819450 |doi=
*cite journal | author=Fröhlich O, Po C, Young LG |title=Organization of the human gene encoding the epididymis-specific EP2 protein variants and its relationship to defensin genes. |journal=Biol. Reprod. |volume=64 |issue= 4 |pages= 1072–9 |year= 2001 |pmid= 11259252 |doi=
*cite journal | author=von Horsten HH, Derr P, Kirchhoff C |title=Novel antimicrobial peptide of human epididymal duct origin. |journal=Biol. Reprod. |volume=67 |issue= 3 |pages= 804–13 |year= 2003 |pmid= 12193388 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Légaré C, Verville N, Sullivan R |title=Vasectomy influences expression of HE1 but not HE2 and HE5 genes in human epididymis. |journal=J. Androl. |volume=25 |issue= 1 |pages= 30–43 |year= 2004 |pmid= 14662784 |doi=
*cite journal | author=Avellar MC, Honda L, Hamil KG, "et al." |title=Differential expression and antibacterial activity of epididymis protein 2 isoforms in the male reproductive tract of human and rhesus monkey (Macaca mulatta). |journal=Biol. Reprod. |volume=71 |issue= 5 |pages= 1453–60 |year= 2005 |pmid= 15229135 |doi= 10.1095/biolreprod.104.031740

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes