- SH2B3
SH2B adaptor protein 3, also known as SH2B3, is a human
gene .cite web | title = Entrez Gene: SH2B3 SH2B adaptor protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10019| accessdate = ]PBB_Summary
section_title =
summary_text = T-cell activation requires stimulation of the T-cell receptor (TCR; see MIM 186880)-CD3 (see CD3Z; MIM 186780) complex, followed by recruitment of an array of intracellular signaling proteins (e.g., GRB2 (MIM 108355) and PLCG1 (MIM 172420)). Mediating the interaction between the extracellular receptors and intracellular signaling pathways are adaptor proteins such as LAT (MIM 602354), TRIM (MIM 604962), and LNK. [supplied by OMIM] cite web | title = Entrez Gene: SH2B3 SH2B adaptor protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10019| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Motto DG, Musci MA, Ross SE, Koretzky GA |title=Tyrosine phosphorylation of Grb2-associated proteins correlates with phospholipase C gamma 1 activation in T cells. |journal=Mol. Cell. Biol. |volume=16 |issue= 6 |pages= 2823–9 |year= 1996 |pmid= 8649391 |doi=
*cite journal | author=Hendricks-Taylor LR, Motto DG, Zhang J, "et al." |title=SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1363–7 |year= 1997 |pmid= 8995445 |doi=
*cite journal | author=Takaki S, Watts JD, Forbush KA, "et al." |title=Characterization of Lnk. An adaptor protein expressed in lymphocytes. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14562–70 |year= 1997 |pmid= 9169414 |doi=
*cite journal | author=Li Y, He X, Schembri-King J, "et al." |title=Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation. |journal=J. Immunol. |volume=164 |issue= 10 |pages= 5199–206 |year= 2000 |pmid= 10799879 |doi=
*cite journal | author=He X, Li Y, Schembri-King J, "et al." |title=Identification of actin binding protein, ABP-280, as a binding partner of human Lnk adaptor protein. |journal=Mol. Immunol. |volume=37 |issue= 10 |pages= 603–12 |year= 2001 |pmid= 11163396 |doi=
*cite journal | author=Takaki S, Morita H, Tezuka Y, Takatsu K |title=Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk. |journal=J. Exp. Med. |volume=195 |issue= 2 |pages= 151–60 |year= 2002 |pmid= 11805142 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Fitau J, Boulday G, Coulon F, "et al." |title=The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways. |journal=J. Biol. Chem. |volume=281 |issue= 29 |pages= 20148–59 |year= 2006 |pmid= 16644735 |doi= 10.1074/jbc.M510997200
*cite journal | author=Wan M, Li Y, Xue H, "et al." |title=TNF-alpha induces Lnk expression through PI3K-dependent signaling pathway in human umbilical vein endothelial cells. |journal=J. Surg. Res. |volume=136 |issue= 1 |pages= 53–7 |year= 2006 |pmid= 17007883 |doi= 10.1016/j.jss.2006.07.004PBB_Controls
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