KIAA0319

KIAA0319, also known as KIAA0319, is a human gene.cite web | title = Entrez Gene: KIAA0319 KIAA0319| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9856| accessdate = ]

PBB_Summary
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summary_text = Reading disability, or dyslexia, is a major social, educational, and mental health problem. In spite of average intelligence and adequate educational opportunities, 5 to 10% of school children have substantial reading deficits. Twin and family studies have shown a substantial genetic component to the disorder, with heritable variation estimated at 50 to 70% (see MIM 127700). [supplied by OMIM] cite web | title = Entrez Gene: KIAA0319 KIAA0319| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9856| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ozçelik T, Porteus MH, Rubenstein JL, Francke U |title=DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2. |journal=Genomics |volume=13 |issue= 4 |pages= 1157–61 |year= 1992 |pmid= 1354641 |doi=
*cite journal | author=Cardon LR, Smith SD, Fulker DW, "et al." |title=Quantitative trait locus for reading disability on chromosome 6. |journal=Science |volume=266 |issue= 5183 |pages= 276–9 |year= 1994 |pmid= 7939663 |doi=
*cite journal | author=Nagase T, Ishikawa K, Nakajima D, "et al." |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141–50 |year= 1997 |pmid= 9205841 |doi=
*cite journal | author=Gayán J, Smith SD, Cherny SS, "et al." |title=Quantitative-trait locus for specific language and reading deficits on chromosome 6p. |journal=Am. J. Hum. Genet. |volume=64 |issue= 1 |pages= 157–64 |year= 1999 |pmid= 9915954 |doi=
*cite journal | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Londin ER, Meng H, Gruen JR |title=A transcription map of the 6p22.3 reading disability locus identifying candidate genes. |journal=BMC Genomics |volume=4 |issue= 1 |pages= 25 |year= 2004 |pmid= 12834540 |doi= 10.1186/1471-2164-4-25
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Francks C, Paracchini S, Smith SD, "et al." |title=A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States. |journal=Am. J. Hum. Genet. |volume=75 |issue= 6 |pages= 1046–58 |year= 2005 |pmid= 15514892 |doi= 10.1086/426404
*cite journal | author=Cope N, Harold D, Hill G, "et al." |title=Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. |journal=Am. J. Hum. Genet. |volume=76 |issue= 4 |pages= 581–91 |year= 2005 |pmid= 15717286 |doi= 10.1086/429131
*cite journal | author=Paracchini S, Thomas A, Castro S, "et al." |title=The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration. |journal=Hum. Mol. Genet. |volume=15 |issue= 10 |pages= 1659–66 |year= 2006 |pmid= 16600991 |doi= 10.1093/hmg/ddl089
*cite journal | author=Luciano M, Lind PA, Duffy DL, "et al." |title=A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability. |journal=Biol. Psychiatry |volume=62 |issue= 7 |pages= 811–7 |year= 2007 |pmid= 17597587 |doi= 10.1016/j.biopsych.2007.03.007
*cite journal | author=Velayos-Baeza A, Toma C, da Roza S, "et al." |title=Alternative splicing in the dyslexia-associated gene KIAA0319. |journal=Mamm. Genome |volume=18 |issue= 9 |pages= 627–34 |year= 2008 |pmid= 17846832 |doi= 10.1007/s00335-007-9051-3

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External links

* [http://www.nextbio.com/b/home/home.nb?q=KIAA0319 KIAA0319 Associations, Experiments, Publications and Clinical Trials]