XAGE1D

X antigen family, member 1, also known as XAGE1, is a human gene.cite web | title = Entrez Gene: XAGE1 X antigen family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9503| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 3 transcript variants, and one of which includes 2 transcripts generated from alternate transcription initiation sites.cite web | title = Entrez Gene: XAGE1 X antigen family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9503| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Brinkmann U, Vasmatzis G, Lee B, Pastan I |title=Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database. |journal=Cancer Res. |volume=59 |issue= 7 |pages= 1445–8 |year= 1999 |pmid= 10197611 |doi=
*cite journal | author=Liu XF, Helman LJ, Yeung C, "et al." |title=XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma. |journal=Cancer Res. |volume=60 |issue= 17 |pages= 4752–5 |year= 2000 |pmid= 10987281 |doi=
*cite journal | author=Zendman AJ, van Kraats AA, den Hollander AI, "et al." |title=Characterization of XAGE-1b, a short major transcript of cancer/testis-associated gene XAGE-1, induced in melanoma metastasis. |journal=Int. J. Cancer |volume=97 |issue= 2 |pages= 195–204 |year= 2002 |pmid= 11774264 |doi=
*cite journal | author=Zendman AJ, Van Kraats AA, Weidle UH, "et al." |title=The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. |journal=Int. J. Cancer |volume=99 |issue= 3 |pages= 361–9 |year= 2002 |pmid= 11992404 |doi= 10.1002/ijc.10371
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Egland KA, Kumar V, Duray P, Pastan I |title=Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers. |journal=Mol. Cancer Ther. |volume=1 |issue= 7 |pages= 441–50 |year= 2003 |pmid= 12479262 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ross MT, Grafham DV, Coffey AJ, "et al." |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440
*cite journal | author=Lim JH, Kim SP, Gabrielson E, "et al." |title=Activation of human cancer/testis antigen gene, XAGE-1, in tumor cells is correlated with CpG island hypomethylation. |journal=Int. J. Cancer |volume=116 |issue= 2 |pages= 200–6 |year= 2005 |pmid= 15800911 |doi= 10.1002/ijc.21007
*cite journal | author=Nakagawa K, Noguchi Y, Uenaka A, "et al." |title=XAGE-1 expression in non-small cell lung cancer and antibody response in patients. |journal=Clin. Cancer Res. |volume=11 |issue= 15 |pages= 5496–503 |year= 2006 |pmid= 16061866 |doi= 10.1158/1078-0432.CCR-05-0216
*cite journal | author=Sato S, Noguchi Y, Ohara N, "et al." |title=Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors. |journal=Cancer Immun. |volume=7 |issue= |pages= 5 |year= 2007 |pmid= 17335148 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes