GGPS1

Geranylgeranyl diphosphate synthase 1, also known as GGPS1, is a human gene.cite web | title = Entrez Gene: GGPS1 geranylgeranyl diphosphate synthase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9453| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.cite web | title = Entrez Gene: GGPS1 geranylgeranyl diphosphate synthase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9453| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ericsson J, Runquist M, Thelin A, "et al." |title=Distribution of prenyltransferases in rat tissues. Evidence for a cytosolic all-trans-geranylgeranyl diphosphate synthase. |journal=J. Biol. Chem. |volume=268 |issue= 2 |pages= 832–8 |year= 1993 |pmid= 8419360 |doi=
*cite journal | author=Ericsson J, Greene JM, Carter KC, "et al." |title=Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression. |journal=J. Lipid Res. |volume=39 |issue= 9 |pages= 1731–9 |year= 1998 |pmid= 9741684 |doi=
*cite journal | author=Kuzuguchi T, Morita Y, Sagami I, "et al." |title=Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. |journal=J. Biol. Chem. |volume=274 |issue= 9 |pages= 5888–94 |year= 1999 |pmid= 10026212 |doi=
*cite journal | author=Kainou T, Kawamura K, Tanaka K, "et al." |title=Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human. |journal=Biochim. Biophys. Acta |volume=1437 |issue= 3 |pages= 333–40 |year= 1999 |pmid= 10101267 |doi=
*cite journal | author=Hu RM, Han ZG, Song HD, "et al." |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997
*cite journal | author=Bommel H, Xie G, Rossoll W, "et al." |title=Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease. |journal=J. Cell Biol. |volume=159 |issue= 4 |pages= 563–9 |year= 2003 |pmid= 12446740 |doi= 10.1083/jcb.200208001
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kavanagh KL, Dunford JE, Bunkoczi G, "et al." |title=The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding. |journal=J. Biol. Chem. |volume=281 |issue= 31 |pages= 22004–12 |year= 2006 |pmid= 16698791 |doi= 10.1074/jbc.M602603200
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Ma J, Dempsey AA, Stamatiou D, "et al." |title=Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. |journal=Atherosclerosis |volume=191 |issue= 1 |pages= 63–72 |year= 2007 |pmid= 16806233 |doi= 10.1016/j.atherosclerosis.2006.05.032
*cite journal | author=Raz T, Nardi V, Azam M, "et al." |title=Farnesyl transferase inhibitor resistance probed by target mutagenesis. |journal=Blood |volume=110 |issue= 6 |pages= 2102–9 |year= 2007 |pmid= 17536018 |doi= 10.1182/blood-2006-12-064907

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