- CHRFAM7A
CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion, also known as CHRFAM7A, is a human
gene .cite web | title = Entrez Gene: CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=89832| accessdate = ]PBB_Summary
section_title =
summary_text = The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.cite web | title = Entrez Gene: CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=89832| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Gault J, Robinson M, Berger R, "et al." |title=Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7). |journal=Genomics |volume=52 |issue= 2 |pages= 173–85 |year= 1998 |pmid= 9782083 |doi= 10.1006/geno.1998.5363
*cite journal | author=Freedman R, Leonard S, Gault JM, "et al." |title=Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7). |journal=Am. J. Med. Genet. |volume=105 |issue= 1 |pages= 20–2 |year= 2001 |pmid= 11424985 |doi=
*cite journal | author=Riley B, Williamson M, Collier D, "et al." |title=A 3-Mb map of a large Segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14. |journal=Genomics |volume=79 |issue= 2 |pages= 197–209 |year= 2002 |pmid= 11829490 |doi= 10.1006/geno.2002.6694
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Trombino S, Cesario A, Margaritora S, "et al." |title=Alpha7-nicotinic acetylcholine receptors affect growth regulation of human mesothelioma cells: role of mitogen-activated protein kinase pathway. |journal=Cancer Res. |volume=64 |issue= 1 |pages= 135–45 |year= 2004 |pmid= 14729617 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Bale AS, Meacham CA, Benignus VA, "et al." |title=Volatile organic compounds inhibit human and rat neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. |journal=Toxicol. Appl. Pharmacol. |volume=205 |issue= 1 |pages= 77–88 |year= 2005 |pmid= 15885267 |doi= 10.1016/j.taap.2004.09.011
*cite journal | author=Freedman R, Leonard S, Waldo M, "et al." |title=Characterization of allelic variants at chromosome 15q14 in schizophrenia. |journal=Genes Brain Behav. |volume=5 Suppl 1 |issue= |pages= 14–22 |year= 2006 |pmid= 16417613 |doi= 10.1111/j.1601-183X.2006.00190.x
*cite journal | author=Zody MC, Garber M, Sharpe T, "et al." |title=Analysis of the DNA sequence and duplication history of human chromosome 15. |journal=Nature |volume=440 |issue= 7084 |pages= 671–5 |year= 2006 |pmid= 16572171 |doi= 10.1038/nature04601
*cite journal | author=Dempster EL, Toulopoulou T, McDonald C, "et al." |title=Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene. |journal=The American journal of psychiatry |volume=163 |issue= 10 |pages= 1832–4 |year= 2006 |pmid= 17012698 |doi= 10.1176/appi.ajp.163.10.1832
*cite journal | author=Martin LF, Leonard S, Hall MH, "et al." |title=Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar type. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=144 |issue= 5 |pages= 611–4 |year= 2007 |pmid= 17192894 |doi= 10.1002/ajmg.b.30470PBB_Controls
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