LARGE

LARGE

Like-glycosyltransferase, also known as LARGE, is a human gene.cite web | title = Entrez Gene: LARGE like-glycosyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9215| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. The function of this gene has not yet been established; however, it may involve a role in tumor-specific genomic rearrangements. Mutations in this gene may be involved in the development and progression of meningioma through modification of ganglioside composition and other glycosylated molecules in tumor cells. Alternative splicing of this gene results in two transcript variants that encode the same protein.cite web | title = Entrez Gene: LARGE like-glycosyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9215| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagase T, Ishikawa K, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=
*cite journal | author=Peyrard M, Seroussi E, Sandberg-Nordqvist AC, "et al." |title=The human LARGE gene from 22q12.3-q13.1 is a new, distinct member of the glycosyltransferase gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 2 |pages= 598–603 |year= 1999 |pmid= 9892679 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Longman C, Brockington M, Torelli S, "et al." |title=Mutations in the human LARGE gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. |journal=Hum. Mol. Genet. |volume=12 |issue= 21 |pages= 2853–61 |year= 2004 |pmid= 12966029 |doi= 10.1093/hmg/ddg307
*cite journal | author=Kanagawa M, Saito F, Kunz S, "et al." |title=Molecular recognition by LARGE is essential for expression of functional dystroglycan. |journal=Cell |volume=117 |issue= 7 |pages= 953–64 |year= 2004 |pmid= 15210115 |doi= 10.1016/j.cell.2004.06.003
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Brockington M, Torelli S, Prandini P, "et al." |title=Localization and functional analysis of the LARGE family of glycosyltransferases: significance for muscular dystrophy. |journal=Hum. Mol. Genet. |volume=14 |issue= 5 |pages= 657–65 |year= 2005 |pmid= 15661757 |doi= 10.1093/hmg/ddi062
*cite journal | author=Fujimura K, Sawaki H, Sakai T, "et al." |title=LARGE2 facilitates the maturation of alpha-dystroglycan more effectively than LARGE. |journal=Biochem. Biophys. Res. Commun. |volume=329 |issue= 3 |pages= 1162–71 |year= 2005 |pmid= 15752776 |doi= 10.1016/j.bbrc.2005.02.082
*cite journal | author=Grewal PK, McLaughlan JM, Moore CJ, "et al." |title=Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies. |journal=Glycobiology |volume=15 |issue= 10 |pages= 912–23 |year= 2006 |pmid= 15958417 |doi= 10.1093/glycob/cwi094

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую
Synonyms:
, , , , , , / , , , , / , , , , , / , / , , , ,


Look at other dictionaries:

  • large — large …   Dictionnaire des rimes

  • large — [ larʒ ] adj., n. m. et adv. • XIe ; lat. largus « abondant; généreux », a remplacé latus, à cause de longus « long » I ♦ Adj. 1 ♦ Qui a une étendue supérieure à la moyenne dans le sens de la largeur. Une large avenue. Chapeau à larges bords.… …   Encyclopédie Universelle

  • Large — (l[aum]rj), a. [Compar. {Larger} (l[aum]r j[ e]r); superl. {Largest}.] [F., fr. L. largus. Cf. {Largo}.] 1. Exceeding most other things of like kind in bulk, capacity, quantity, superficial dimensions, or number of constituent units; big; great;… …   The Collaborative International Dictionary of English

  • large — [ lardʒ ] adjective *** bigger than usual in size: The house had an exceptionally large yard. Large crowds gather each year in St. Peter s Square to see the Pope. A large man with a long ginger beard stood in the doorway. a. used in clothing… …   Usage of the words and phrases in modern English

  • large — [lärj] adj. larger, largest [OFr < L largus: see LARD] 1. Archaic liberal; generous 2. big; great; specif., a) taking up much space; bulky b) enclosing much space; spacious [a large office] …   English World dictionary

  • large — large, big, great mean above the average of its kind in magnitude, especially physical magnitude. Large may be preferred when the dimensions, or extent, or capacity, or quantity, or amount is being considered {a large lot} {a large hall} {a large …   New Dictionary of Synonyms

  • large — Large, Latus, Largus, Laxus. Large par le bas et allant en aguisant, Pyramidatus. Fort large, Perlatus. Fort large et spatieux, Spatiosus. Large outre mesure, Vastus. Un homme large, soit prodigue ou liberal, Largus. Trop large, Nimius. Devenir… …   Thresor de la langue françoyse

  • large — 〈[la:(r)dʒ] Abk.: L〉 groß (als Kleidergröße) [engl.] * * * 1large [larʒ(ə) ] <Adj.> [frz. large < lat. largus = freigebig; reichlich] (bes. schweiz.): großzügig: der l. Schiedsrichter. 2large [la:ɐ̯d̮ʒ ] <indekl. Adj.> [engl. large …   Universal-Lexikon

  • Large — ist der Familienname folgender Personen: Brian Large (* 1939), Fernsehregisseur von Opernübertragungen Josaphat Robert Large (* 1942), Dichter und Romancier Robert C. De Large (1842−1874), US amerikanischer Politiker Diese …   Deutsch Wikipedia

  • large — large, largely Large is used as an adverb with the verbs bulk and loom and in the phrase by and large. Otherwise largely is the normal adverb and means ‘to a large extent’ (His failure was largely due to laziness) …   Modern English usage

  • large — ► ADJECTIVE 1) of considerable or relatively great size, extent, or capacity. 2) pursuing an occupation or activity on a significant scale. 3) of wide range or scope. ► VERB (large it) Brit. informal ▪ go out and have a good time. ● …   English terms dictionary

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”