GFM1

G elongation factor, mitochondrial 1, also known as GFM1, is a human gene.cite web | title = Entrez Gene: GFM1 G elongation factor, mitochondrial 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85476| accessdate = ]

PBB_Summary
section_title =
summary_text = Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known.cite web | title = Entrez Gene: GFM1 G elongation factor, mitochondrial 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85476| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bec G, Kerjan P, Zha XD, Waller JP |title=Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1. |journal=J. Biol. Chem. |volume=264 |issue= 35 |pages= 21131–7 |year= 1990 |pmid= 2556394 |doi=
*cite journal | author=Motorin YuA , Wolfson AD, Orlovsky AF, Gladilin KL |title=Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor. |journal=FEBS Lett. |volume=238 |issue= 2 |pages= 262–4 |year= 1988 |pmid= 3169261 |doi=
*cite journal | author=Gao J, Yu L, Zhang P, "et al." |title=Cloning and characterization of human and mouse mitochondrial elongation factor G, GFM and Gfm, and mapping of GFM to human chromosome 3q25.1-q26.2. |journal=Genomics |volume=74 |issue= 1 |pages= 109–14 |year= 2001 |pmid= 11374907 |doi= 10.1006/geno.2001.6536
*cite journal | author=Hammarsund M, Wilson W, Corcoran M, "et al." |title=Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution. |journal=Hum. Genet. |volume=109 |issue= 5 |pages= 542–50 |year= 2001 |pmid= 11735030 |doi= 10.1007/s00439-001-0610-5
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Bhargava K, Templeton P, Spremulli LL |title=Expression and characterization of isoform 1 of human mitochondrial elongation factor G. |journal=Protein Expr. Purif. |volume=37 |issue= 2 |pages= 368–76 |year= 2005 |pmid= 15358359 |doi= 10.1016/j.pep.2004.06.030
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Coenen MJ, Antonicka H, Ugalde C, "et al." |title=Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency. |journal=N. Engl. J. Med. |volume=351 |issue= 20 |pages= 2080–6 |year= 2004 |pmid= 15537906 |doi= 10.1056/NEJMoa041878
*cite journal | author=Antonicka H, Sasarman F, Kennaway NG, Shoubridge EA |title=The molecular basis for tissue specificity of the oxidative phosphorylation deficiencies in patients with mutations in the mitochondrial translation factor EFG1. |journal=Hum. Mol. Genet. |volume=15 |issue= 11 |pages= 1835–46 |year= 2006 |pmid= 16632485 |doi= 10.1093/hmg/ddl106
*cite journal | author=Valente L, Tiranti V, Marsano RM, "et al." |title=Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu. |journal=Am. J. Hum. Genet. |volume=80 |issue= 1 |pages= 44–58 |year= 2007 |pmid= 17160893 |doi= 10.1086/510559

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes