(-)-Methyl-1-methyl-4β-(2-naphthyl)piperidine-3β-carboxylate

Drugbox
IUPAC_name = methyl (3S,4S)-1-methyl-4-naphthalen-2-ylpiperidine-3-carboxylate


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PubChem= 10684403
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C=18 | H=21 | N=1 | O=2
molecular_weight = 283.364
smiles = COC(=O)C1CN(C)CCC1c3ccc2ccccc2c3
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(-)-Methyl-1-methyl-4β-(2-naphthyl)piperidine-3β-carboxylate is a piperidine based stimulant drug which is synthesised from arecoline. It is similar to nocaine in chemical structure, and has two and a half times more activity than cocaine as a dopamine reuptake inhibitor. However it is also a potent serotonin reuptake inhibitor, with similar affinity to fluoxetine.cite web |url=http://pubs.acs.org/cgi-bin/abstract.cgi/jmcmar/2000/43/i06/abs/jm9905561.html |title=Further SAR Studies of Piperidine-Based Analogues of Cocaine. 2. Potent Dopamine and Serotonin Reuptake Inhibitors |accessdate=2008-01-11 |format= |work=] It is a structural isomer of another potent dopamine reuptake inhibitor, HDMP-28.

References

ee also

*List of cocaine analogues