SPPL2A

Signal peptide peptidase-like 2A, also known as SPPL2A, is a human gene.cite web | title = Entrez Gene: SPPL2A signal peptide peptidase-like 2A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84888| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the signal peptide peptidase-like protease (SPPL) family and encodes an endosomal membrane protein with a protease associated (PA) domain. This protein plays a role in innate and adaptive immunity. A pseudogene of this gene also lies on chromosome 15.cite web | title = Entrez Gene: SPPL2A signal peptide peptidase-like 2A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84888| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Weihofen A, Binns K, Lemberg MK, "et al." |title=Identification of signal peptide peptidase, a presenilin-type aspartic protease. |journal=Science |volume=296 |issue= 5576 |pages= 2215–8 |year= 2002 |pmid= 12077416 |doi= 10.1126/science.1070925
*cite journal | author=Grigorenko AP, Moliaka YK, Korovaitseva GI, Rogaev EI |title=Novel class of polytopic proteins with domains associated with putative protease activity. |journal=Biochemistry Mosc. |volume=67 |issue= 7 |pages= 826–35 |year= 2003 |pmid= 12139484 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Granneman S, Gallagher JE, Vogelzangs J, "et al." |title=The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. |journal=Nucleic Acids Res. |volume=31 |issue= 7 |pages= 1877–87 |year= 2003 |pmid= 12655004 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Friedmann E, Lemberg MK, Weihofen A, "et al." |title=Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. |journal=J. Biol. Chem. |volume=279 |issue= 49 |pages= 50790–8 |year= 2005 |pmid= 15385547 |doi= 10.1074/jbc.M407898200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Otsuki T, Ota T, Nishikawa T, "et al." |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Friedmann E, Hauben E, Maylandt K, "et al." |title=SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production. |journal=Nat. Cell Biol. |volume=8 |issue= 8 |pages= 843–8 |year= 2006 |pmid= 16829952 |doi= 10.1038/ncb1440
*cite journal | author=Kirkin V, Cahuzac N, Guardiola-Serrano F, "et al." |title=The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells. |journal=Cell Death Differ. |volume=14 |issue= 9 |pages= 1678–87 |year= 2007 |pmid= 17557115 |doi= 10.1038/sj.cdd.4402175

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