XYLT2

Xylosyltransferase II, also known as XYLT2, is a human gene.cite web | title = Entrez Gene: XYLT2 xylosyltransferase II| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64132| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis.cite web | title = Entrez Gene: XYLT2 xylosyltransferase II| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64132| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Götting C, Kuhn J, Brinkmann T, Kleesiek K |title=Xylosylation of alternatively spliced isoforms of Alzheimer APP by xylosyltransferase. |journal=J. Protein Chem. |volume=17 |issue= 3 |pages= 295–302 |year= 1998 |pmid= 9588955 |doi=
*cite journal | author=Götting C, Sollberg S, Kuhn J, "et al." |title=Serum xylosyltransferase: a new biochemical marker of the sclerotic process in systemic sclerosis. |journal=J. Invest. Dermatol. |volume=112 |issue= 6 |pages= 919–24 |year= 1999 |pmid= 10383739 |doi= 10.1046/j.1523-1747.1999.00590.x
*cite journal | author=Kuhn J, Götting C, Schnölzer M, "et al." |title=First isolation of human UDP-D-xylose: proteoglycan core protein beta-D-xylosyltransferase secreted from cultured JAR choriocarcinoma cells. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 4940–7 |year= 2001 |pmid= 11087729 |doi= 10.1074/jbc.M005111200
*cite journal | author=Götting C, Kuhn J, Zahn R, "et al." |title=Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II. |journal=J. Mol. Biol. |volume=304 |issue= 4 |pages= 517–28 |year= 2001 |pmid= 11099377 |doi= 10.1006/jmbi.2000.4261
*cite journal | author=Götting C, Kuhn J, Brinkmann T, Kleesiek K |title=Xylosyltransferase activity in seminal plasma of infertile men. |journal=Clin. Chim. Acta |volume=317 |issue= 1-2 |pages= 199–202 |year= 2002 |pmid= 11814476 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Schön S, Prante C, Müller S, "et al." |title=Impact of polymorphisms in the genes encoding xylosyltransferase I and a homologue in type 1 diabetic patients with and without nephropathy. |journal=Kidney Int. |volume=68 |issue= 4 |pages= 1483–90 |year= 2005 |pmid= 16164625 |doi= 10.1111/j.1523-1755.2005.00561.x
*cite journal | author=Schön S, Prante C, Bahr C, "et al." |title=Cloning and recombinant expression of active full-length xylosyltransferase I (XT-I) and characterization of subcellular localization of XT-I and XT-II. |journal=J. Biol. Chem. |volume=281 |issue= 20 |pages= 14224–31 |year= 2006 |pmid= 16569644 |doi= 10.1074/jbc.M510690200
*cite journal | author=Voglmeir J, Voglauer R, Wilson IB |title=XT-II, the second isoform of human peptide-O-xylosyltransferase, displays enzymatic activity. |journal=J. Biol. Chem. |volume=282 |issue= 9 |pages= 5984–90 |year= 2007 |pmid= 17194707 |doi= 10.1074/jbc.M608087200

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